BDBM540272 (R)-(E)-55-fluoro-6-methyl-3-oxa-7-aza-1(3,6)-imidazo[1,2-b]pyridazina-2(2,4), 5(2,3)-dipyridinacycloheptaphane::US20260028352, Example I-24

SMILES C[C@@H]1Nc2ccc3ncc(n3n2)-c2cncc(c2)OCc2ncc(F)cc21

InChI Key InChIKey=ACRQYMGHQSIJOJ-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 540272   

TargetHigh affinity nerve growth factor receptor(Human)
Suzhou Langrui Biopharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 540272BDBM540272((R)-(E)-55-fluoro-6-methyl-3-oxa-7-aza-1(3,6)-imid...)
Affinity DataIC50: 3nMAssay Description:Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center Affiliation: UT Southwestern Assay Provider: David Mangelsdorf,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2026
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor NTRK1 [F589L](Homo sapiens (Human))
Suzhou Langrui Biopharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 540272BDBM540272((R)-(E)-55-fluoro-6-methyl-3-oxa-7-aza-1(3,6)-imid...)
Affinity DataIC50: 5nMAssay Description:Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center Affiliation: UT Southwestern Assay Provider: David Mangelsdorf,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2026
Entry Details
US Patent