BDBM617472 US20230285393, Compound 020

SMILES O=C(C1CC(F)(F)C1)N1Cc2ccc(-c3nccc(Nc4ccc(-c5cn[nH]c5)cc4)n3)cc2C1

InChI Key InChIKey=PPNGOBGQHGDLAT-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 617472   

TargetRho-associated protein kinase 2 [1-119](Human)
Beijing Tide Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 617472BDBM617472(US20230285393, Compound 020 | US12582653, Compound...)
Affinity DataIC50: 44nMAssay Description:The kinase IC50 was determined by a commercialized CISBIO kinase detection kit, HTRF KinEASE-STK S2 kit (62ST2PEC). ROCK2 (01-119) employed in the re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2023
Entry Details
US Patent

TargetRho-associated protein kinase 2(Human)
Beijing Tide Pharmaceutical Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 617472BDBM617472(US20230285393, Compound 020 | US12582653, Compound...)
Affinity DataIC50: 44nMAssay Description:NMDA receptors are ion channels that are highly permeable to Ca2+ ions, rendering it possible to monitor NMDA receptor function using cell-based calc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/3/2026
Entry Details
US Patent