BDBM631071 (3S,4S) or (3R,4R) 4-[4-(2-{[1- (bicyclo[1.1.1]pentan-1-yl)-5- methyl-1H-pyrazol-4-yl]amino}-6- chloroquinazolin-7-yl)piperidin-1- yl]oxolan-3-ol::US12540131, Ex-2.28

SMILES Cc1c(Nc2ncc3cc(Cl)c(C4CCN([C@@H]5COC[C@@H]5O)CC4)cc3n2)cnn1C12CC(C1)C2

InChI Key InChIKey=YLBQJFVQRNCSKB-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 631071   

TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 631071BDBM631071((3S,4S) or (3R,4R) 4-[4-(2-{[1- (bicyclo[1.1.1]pen...)
Affinity DataIC50: 0.631nMAssay Description:The ability of compounds to modulate production of amyloid beta protein Abeta(1-42) was determined using human WT-APP overexpressing CHO cells. Cells...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/15/2026
Entry Details
US Patent