BDBM639352 6-chloro-N-{1-[3- (methoxymethyl)bicyclo[1.1.1] pentan-1-yl]-5-methyl-1H- pyrazol-4-yl}-7-[1-(oxetan-3-yl) piperidin-4-yl]quinazolin-2-amine::US12540131, Ex-2.31

SMILES COCC12CC(n3ncc(Nc4ncc5cc(Cl)c(C6CCN(C7COC7)CC6)cc5n4)c3C)(C1)C2

InChI Key InChIKey=NLPQDNIUUNADNA-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 639352   

TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 639352BDBM639352(6-chloro-N-{1-[3- (methoxymethyl)bicyclo[1.1.1] pe...)
Affinity DataIC50: 0.631nMAssay Description:The ability of compounds to modulate production of amyloid beta protein Abeta(1-42) was determined using human WT-APP overexpressing CHO cells. Cells...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/15/2026
Entry Details
US Patent