BDBM655279 2-(6-(4-fluoro-3-isopropyl-2-(8-methoxy-[1,2,4]triazolo[1,5-a]pyridin-6-yl)-1H-pyrrolo[2,3-c]pyridin-5-yl)-2,6-diazaspiro[3.3]heptan-2-yl)-N-methylacetamide::US11912703, Example 356

SMILES CNC(=O)CN1CC2(C1)CN(C2)c1ncc2[nH]c(c(C(C)C)c2c1F)-c1cc(OC)c2ncnn2c1

InChI Key InChIKey=YCFURVMYHHZBFM-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 655279   

TargetToll-like receptor 8(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM655279(US11912703, Example 356 | 2-(6-(4-fluoro-3-isoprop...)
Affinity DataIC50: 6.10nMAssay Description:HEK-Blue-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducible...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/3/2024
Entry Details
US Patent

TargetToll-like receptor 7(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM655279(US11912703, Example 356 | 2-(6-(4-fluoro-3-isoprop...)
Affinity DataIC50: 15nMAssay Description:HEK-Blue-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducible...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/3/2024
Entry Details
US Patent

TargetToll-like receptor 9(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM655279(US11912703, Example 356 | 2-(6-(4-fluoro-3-isoprop...)
Affinity DataIC50: 1.85E+4nMAssay Description:HEK-Blue-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducible...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/3/2024
Entry Details
US Patent