BDBM746177 (3S,4S or 3R,4R)-4- ((R)-4-(1-(1- (bicyclo[1.1.1]pentan- 1-yl)-1H-pyrazol-4-yl)- 5-chloro-1H-indazol-6- yl)-2-methylpiperazin- 1-yl)-4- methyltetrahydrofuran- 3-ol::US12319671, Example 7.22

SMILES C[C@@H]1CN(c2cc3c(cnn3-c3cnn(C45CC(C4)C5)c3)cc2Cl)CCN1[C@@]1(C)COC[C@H]1O

InChI Key

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 746177   

TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM746177((3S,4S or 3R,4R)-4- ((R)-4-(1-(1- (bicyclo[1.1.1]p...)
Affinity DataIC50: 1.02E+3nMAssay Description:Assays were performed in the presence of 134 μM ATP (Km ATP). Upon completion, the assay was stopped, and phosphorylated substrate detected with a te...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/25/2025
Entry Details
US Patent