BDBM746883 US20250179047, Example 53

SMILES Cc1c(N(C(=O)c2cc(-c3cc4c(cc3C(=O)N3Cc5ccccc5C[C@H]3C)CN(C(=O)Cc3ccc(OCCN5CCC(F)CC5)cc3)CC4)n(C)c2C)c2ccc(O)cc2)cc(C#N)n1C

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 746883   

TargetApoptosis regulator Bcl-2(Human)
Les Laboratoires Servier

US Patent
LigandPNGBDBM746883(US20250179047, Example 53)
Affinity DataKi:  0.0700nMAssay Description:The assay was performed in a 40 μL volume in white 384-standard well plates (Corning #3574). An 11-point serial dilution of each compound was prepare...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
US Patent

TargetApoptosis regulator Bcl-2 [D111A](Human)
Les Laboratoires Servier

US Patent
LigandPNGBDBM746883(US20250179047, Example 53)
Affinity DataKi:  0.180nMAssay Description:The assay was performed in a 40 μL volume in white 384-standard well plates (Corning #3574). An 11-point serial dilution of each compound was prepare...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
US Patent

TargetApoptosis regulator Bcl-2 [D103Y](Human)
Les Laboratoires Servier

US Patent
LigandPNGBDBM746883(US20250179047, Example 53)
Affinity DataKi:  0.180nMAssay Description:The assay was performed in a 40 μL volume in white 384-standard well plates (Corning #3574). An 11-point serial dilution of each compound was prepare...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
US Patent

TargetApoptosis regulator Bcl-2 [G101V](Human)
Les Laboratoires Servier

US Patent
LigandPNGBDBM746883(US20250179047, Example 53)
Affinity DataKi:  0.200nMAssay Description:The assay was performed in a 40 μL volume in white 384-standard well plates (Corning #3574). An 11-point serial dilution of each compound was prepare...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
US Patent

TargetApoptosis regulator Bcl-2 [F104I](Human)
Les Laboratoires Servier

US Patent
LigandPNGBDBM746883(US20250179047, Example 53)
Affinity DataKi:  0.350nMAssay Description:The assay was performed in a 40 μL volume in white 384-standard well plates (Corning #3574). An 11-point serial dilution of each compound was prepare...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
US Patent

TargetBcl-2-like protein 1(Human)
Les Laboratoires Servier

US Patent
LigandPNGBDBM746883(US20250179047, Example 53)
Affinity DataKi:  1.20nMAssay Description:The assay was performed in a 40 μL volume in white 384-standard well plates (Corning #3574). An 11-point serial dilution of each compound was prepare...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
US Patent