BDBM761638 2-(6-bromo-1-oxo-1,3-dihydro- 2H-pyrrolo[3,4-c]pyridin-2-yl)- 2-(3-fluorophenyl)-N-(thiazol- 2-yl)acetamide::US12377080, Compound 1

SMILES O=C(Nc1nccs1)C(c1cccc(F)c1)N1Cc2cnc(Br)cc2C1=O

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 761638   

TargetEpidermal growth factor receptor [T790M,L858R](Human)
Dana-Farber Cancer Institute

US Patent
LigandPNGBDBM761638(2-(6-bromo-1-oxo-1,3-dihydro- 2H-pyrrolo[3,4-c]pyr...)
Affinity DataIC50: 104nMAssay Description:EGFR biochemical activity measurements were carried out using the homogeneous time-resolved fluorescence (HTRF) assay (Cisbio). Inhibitors and DMSO n...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
US Patent

TargetEpidermal growth factor receptor [L858R](Human)
Dana-Farber Cancer Institute

US Patent
LigandPNGBDBM761638(2-(6-bromo-1-oxo-1,3-dihydro- 2H-pyrrolo[3,4-c]pyr...)
Affinity DataIC50: 1.00E+3nMAssay Description:EGFR biochemical activity measurements were carried out using the homogeneous time-resolved fluorescence (HTRF) assay (Cisbio). Inhibitors and DMSO n...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
US Patent