BDBM7726 (3Z)-N-(3-hydroxy-2,2-dimethylpropyl)-2-oxo-3-[2-(4-sulfamoylphenyl)hydrazin-1-ylidene]-2,3-dihydro-1H-indole-5-carboxamide::3-{[4-(Aaminosulfonyl)phenyl]hydrazono}-N-(3-hydroxy-2,2-dimethylpropyl)-2-oxo-5-indolinecarboxamide::Oxindole-Based Inhibitor 62

SMILES CC(C)(CO)CNC(=O)c1ccc2NC(=O)C(=NNc3ccc(cc3)S(N)(=O)=O)c2c1

InChI Key InChIKey=ZOVGOJSKGVLAJH-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 7726   

TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM7726((3Z)-N-(3-hydroxy-2,2-dimethylpropyl)-2-oxo-3-[2-(...)
Affinity DataIC50:  60nMAssay Description:The biochemical activity of compounds was determined by incubation with specific enzymes and substrates in the presence 1.4 uM ATP/[gamma-32P] ATP. A...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
University Of Zurich

Curated by ChEMBL
LigandPNGBDBM7726((3Z)-N-(3-hydroxy-2,2-dimethylpropyl)-2-oxo-3-[2-(...)
Affinity DataIC50:  6.80nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 1(Homo sapiens (Human))
University Of Zurich

Curated by ChEMBL
LigandPNGBDBM7726((3Z)-N-(3-hydroxy-2,2-dimethylpropyl)-2-oxo-3-[2-(...)
Affinity DataIC50:  60nMAssay Description:Inhibition of CDK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM7726((3Z)-N-(3-hydroxy-2,2-dimethylpropyl)-2-oxo-3-[2-(...)
Affinity DataIC50:  6.80nMAssay Description:The biochemical activity of compounds was determined by incubation with specific enzymes and substrates in the presence 1.4 uM ATP/[gamma-32P] ATP. A...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed