BDBM799231 N-(5-(4-(4- acetylpiperazin- 1-yl)piperidin-1- yl)-2-((5-cyano- 4-((2- isopropoxyphenyl) amino)pyrimidin- 2- yl)amino)phenyl) acrylamide::US12582654, Example 50

SMILES C=CC(=O)Nc1cc(N2CCC(N3CCN(C(C)=O)CC3)CC2)ccc1Nc1ncc(C#N)c(Nc2ccccc2OC(C)C)n1

InChI Key InChIKey=YWHCHGXEXWDVSG-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 799231   

TargetFibroblast growth factor receptor 4 [V550L](Human)
Beijing Scitech-MQ Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 799231BDBM799231(N-(5-(4-(4- acetylpiperazin- 1-yl)piperidin-1- yl)...)
Affinity DataIC50: 10nMAssay Description:This example demonstrates the ability of the compounds of the disclosure to degrade a Nano luciferase-BRO9 fusion protein in a cell-based degradation...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
8/3/2026
Entry Details
US Patent

TargetFibroblast growth factor receptor 4(Human)
Beijing Scitech-MQ Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 799231BDBM799231(N-(5-(4-(4- acetylpiperazin- 1-yl)piperidin-1- yl)...)
Affinity DataIC50: 30nMAssay Description:This example demonstrates the ability of the compounds of the disclosure to degrade a Nano luciferase-BRO9 fusion protein in a cell-based degradation...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
8/3/2026
Entry Details
US Patent