BDBM50047023 Clorgiline::US20250382276, Compound Clorgyline::[3-(2,3-Dichloro-phenoxy)-propyl]-methyl-prop-2-ynyl-amine (clorgyline)

SMILES C#CCN(C)CCCOc1ccc(Cl)cc1Cl

InChI Key InChIKey=BTFHLQRNAMSNLC-UHFFFAOYSA-N

Data  6 IC50

PDB links: 3 PDB IDs match this monomer.

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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50047023   

TargetAmine oxidase [flavin-containing] A(Human)
Zhengzhou University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50047023BDBM50047023([3-(2,3-Dichloro-phenoxy)-propyl]-methyl-prop-2-yn...)
Affinity DataIC50: 1.90nMAssay Description:Inhibition of MAO-A (unknown origin) assessed as luminescent signal by MAO-Glo-assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetAmine oxidase [flavin-containing] A(Human)
Zhengzhou University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50047023BDBM50047023([3-(2,3-Dichloro-phenoxy)-propyl]-methyl-prop-2-yn...)
Affinity DataIC50: 3nMAssay Description:Inhibition of human MAO-A expressed in baculovirus infected BTI-TN-5B1-4 insect cells using kynuramine as substrate incubated for 10 10 mins by spect...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetAmine oxidase [flavin-containing] A(Human)
Zhengzhou University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50047023BDBM50047023([3-(2,3-Dichloro-phenoxy)-propyl]-methyl-prop-2-yn...)
Affinity DataIC50: 7.70nMAssay Description:Keywords: Heat Shock Factor-1 (HSF-1), Stress Response, MG132, NIH3T3, Luminescence Assay Overview: Modified NIH3T3, transformed to express firefly...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/29/2026
Entry Details
US Patent
PDB3D3D Structure (crystal)
TargetAmine oxidase [flavin-containing] A(Human)
Zhengzhou University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50047023BDBM50047023([3-(2,3-Dichloro-phenoxy)-propyl]-methyl-prop-2-yn...)
Affinity DataIC50: 18nMAssay Description:Inhibition of human recombinant MAO-A using kynuramine as substrate preincubated for 15 mins followed by enzyme addition and measured after 20 mins b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetAmine oxidase [flavin-containing] A(Human)
Zhengzhou University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50047023BDBM50047023([3-(2,3-Dichloro-phenoxy)-propyl]-methyl-prop-2-yn...)
Affinity DataIC50: 147nMAssay Description:Inhibition of human MAO-A preincubated with compound for 10 mins followed by substrate addition and measured after 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetAmine oxidase [flavin-containing] B(Human)
University of Florence

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50047023BDBM50047023([3-(2,3-Dichloro-phenoxy)-propyl]-methyl-prop-2-yn...)
Affinity DataIC50: 2.50E+3nMAssay Description:Inhibition of human MAO-B expressed in baculovirus infected BTI-TN-5B1-4 insect cells using kynuramine as substrate incubated for 10 10 mins by spect...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed