BDBM50338602 (3-Chloro-4-fluoro-phenyl)-[7-methoxy-6-(2-morpholin-4-yl-ethoxy)-quinazolin-4-yl]-amine::(3-Chloro-4-fluoro-phenyl)-[7-methoxy-6-(3-morpholin-4-yl-propoxy)-quinazolin-4-yl]-amine::3-CHLORO-4-FLUORO-N-[(4Z)-7-METHOXY-6-(3-MORPHOLIN-4-YLPROPOXY)QUINAZOLIN-4(1H)-YLIDENE]ANILINE::CHEMBL939::Iressa::N-(3-chloro-4-fluorophenyl)-7-methoxy-6-(3-morpholinopropoxy)quinazolin-4-amine::ZD-1839::gefitinib::gefitnib::gifitinib

SMILES COc3cc2ncnc(Nc1ccc(F)c(Cl)c1)c2cc3OCCCN4CCOCC4

InChI Key InChIKey=XGALLCVXEZPNRQ-UHFFFAOYSA-N

Data  1 KI  5 IC50

PDB links: 10 PDB IDs match this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50338602   

TargetEpidermal growth factor receptor(Human)
Purdue University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50338602BDBM50338602((3-Chloro-4-fluoro-phenyl)-[7-methoxy-6-(2-morphol...)
Affinity DataKi:  0.400nMAssay Description:Binding affinity to EGFR (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetEpidermal growth factor receptor(Human)
Purdue University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50338602BDBM50338602((3-Chloro-4-fluoro-phenyl)-[7-methoxy-6-(2-morphol...)
Affinity DataIC50: 2.20nMAssay Description:Inhibition of EGFR (unknown origin) using ultra ULight GT peptide as substrate incubated for 2 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetEpidermal growth factor receptor(Human)
Purdue University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50338602BDBM50338602((3-Chloro-4-fluoro-phenyl)-[7-methoxy-6-(2-morphol...)
Affinity DataIC50: 7.70nMAssay Description:Inhibition of wild type EGFR (unknown origin) using 4 x ULightTM-labeled JAK-1 (Try1023) peptide substrate measured after 180 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetEpidermal growth factor receptor(Human)
Purdue University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50338602BDBM50338602((3-Chloro-4-fluoro-phenyl)-[7-methoxy-6-(2-morphol...)
Affinity DataIC50: 27nMAssay Description:Inhibition of EGFR (cytoplasmic domain from 669 to 1210) (unknown origin) using Tk-peptide substrate pretreated for 10 mins followed by substrate add...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetVascular endothelial growth factor receptor 2(Human)
Zhengzhou University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50338602BDBM50338602((3-Chloro-4-fluoro-phenyl)-[7-methoxy-6-(2-morphol...)
Affinity DataIC50: 33nMAssay Description:Inhibition of VEGFR2 (unknown origin) by caliper mobility shift assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Purdue University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50338602BDBM50338602((3-Chloro-4-fluoro-phenyl)-[7-methoxy-6-(2-morphol...)
Affinity DataIC50: 43nMAssay Description:Inhibition of human recombinant GST tagged-EGFR using Poly (Glu,Tyr) 4:1 as substrate in presence of ATP by ADP-Glo luminescence kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMedPDB3D3D Structure (crystal)