BDBM50159110 1-(3-(4-(piperidin-1-ylmethyl)phenoxy)propyl)piperidine::1-(4-(3-(piperidin-1-yl)propoxy)benzyl)piperidine::1-[3-(4-hexahydro-1-pyridinylmethylphenoxy)propyl]hexahydropyridine::1-[4-(3-hexahydro-1-pyridinylpropoxy)benzyl]hexahydropyridine::CHEMBL129542::JNJ-5207852
SMILES C(COc1ccc(CN2CCCCC2)cc1)CN1CCCCC1
InChI Key InChIKey=PTKHFRNHJULJKT-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 33 hits for monomerid = 50159110
Affinity DataKi: 0.0603nMAssay Description:Binding affinity in Nluc-hH3R assessed in HEK293 cells by NanoBRET binding assayMore data for this Ligand-Target Pair
Affinity DataKi: 0.200nMAssay Description:Antagonist potency against human H3 receptor in GTPgamma[S]-AssayMore data for this Ligand-Target Pair
Affinity DataKi: 0.209nMAssay Description:Displacement of [3H]UR-P1294 from human H3R receptor expressed in HEK293 cells by radioligand competition binding assayMore data for this Ligand-Target Pair
Affinity DataKi: 0.275nMAssay Description:Binding affinity to human H3RMore data for this Ligand-Target Pair
Affinity DataKi: 0.400nMAssay Description:Displacement of N-[3H]methylhistamine from human histamine H3 receptor expressed in SK-N-MC cellsMore data for this Ligand-Target Pair
Affinity DataKi: 0.570nMAssay Description:Displacement of [3H]N-alpha-methylhistamine from human cloned histamine H3 receptor expressed in monkey COS7 cellsMore data for this Ligand-Target Pair
Affinity DataKi: 0.575nMAssay Description:Binding affinity to human recombinant histamine H3 receptorMore data for this Ligand-Target Pair
TargetHistamine H3 receptor(Rattus norvegicus (rat))
Johann Wolfgang Goethe University
Curated by ChEMBL
Johann Wolfgang Goethe University
Curated by ChEMBL
Affinity DataKi: 0.580nMAssay Description:Binding affinity to rat histamine H3 receptorMore data for this Ligand-Target Pair
Affinity DataKi: 0.580nMAssay Description:Displacement of [125I]iodoproxyfan from human histamine H3 receptor expressed in HEL293 cellsMore data for this Ligand-Target Pair
Affinity DataKi: 0.600nMAssay Description:Displacement of [3H]N-alpha-methylhistamine from human histamine H3 receptor expressed in SK-N-MC cellsMore data for this Ligand-Target Pair
Affinity DataKi: 0.600nMAssay Description:Binding affinity to Homo sapiens (human) H3 receptorMore data for this Ligand-Target Pair
Affinity DataKi: 0.600nMAssay Description:Binding affinity to histamine H3 receptorMore data for this Ligand-Target Pair
Affinity DataKi: 0.600nMAssay Description:Inverse agonist activity at human histamine H3 receptor expressed in SK-N-MC cellsMore data for this Ligand-Target Pair
Affinity DataKi: 0.600nMAssay Description:Displacement of [125I]iodoproxyfan from human recombinant histamine H3 receptor expressed in human SK-N-MC cells after 1 hr by fluid scintillation co...More data for this Ligand-Target Pair
Affinity DataKi: 0.600nMAssay Description:Binding affinity to human histamine H3 receptorMore data for this Ligand-Target Pair
Affinity DataKi: 0.630nMAssay Description:Displacement of [3H]-N-alpha-methylhistamine from human cloned histamine H3 receptor expressed in C6 cellsMore data for this Ligand-Target Pair
TargetHistamine H3 receptor(Rattus norvegicus (rat))
Johann Wolfgang Goethe University
Curated by ChEMBL
Johann Wolfgang Goethe University
Curated by ChEMBL
Affinity DataKi: 0.631nMAssay Description:Binding affinity to rat histamine H3 receptorMore data for this Ligand-Target Pair
Affinity DataKi: 0.631nMAssay Description:Antagonist activity at human histamine H3 receptorMore data for this Ligand-Target Pair
Affinity DataKi: 0.631nMAssay Description:Binding affinity in Nluc-hH3R assessed in HEK293T cells by NanoBRET binding assayMore data for this Ligand-Target Pair
Affinity DataKi: 0.970nMAssay Description:Binding affinity to human histamine H3 receptorMore data for this Ligand-Target Pair
Affinity DataKi: 0.970nMAssay Description:Displacement of [125I]iodoproxyfan from human recombinant histamine H3 receptor expressed in human SK-N-MC cellsMore data for this Ligand-Target Pair
TargetHistamine H3 receptor(Rattus norvegicus (rat))
Johann Wolfgang Goethe University
Curated by ChEMBL
Johann Wolfgang Goethe University
Curated by ChEMBL
Affinity DataKi: 1nMAssay Description:Displacement of N-[3H]methylhistamine from rat histamine H3 receptor in rat cortical hemispheresMore data for this Ligand-Target Pair
Affinity DataKi: 1nMAssay Description:Binding affinity to human histamine H3 receptorMore data for this Ligand-Target Pair
TargetHrh3 protein(RAT)
Johnson & Johnson Pharmaceutical Research and Development
Curated by PDSP Ki Database
Johnson & Johnson Pharmaceutical Research and Development
Curated by PDSP Ki Database
TargetHistamine H3 receptor(Rattus norvegicus (rat))
Johann Wolfgang Goethe University
Curated by ChEMBL
Johann Wolfgang Goethe University
Curated by ChEMBL
Affinity DataKi: 1.26nMAssay Description:Binding affinity to rat histamine H3 receptorMore data for this Ligand-Target Pair
TargetHistamine H3 receptor(Rattus norvegicus (rat))
Johann Wolfgang Goethe University
Curated by ChEMBL
Johann Wolfgang Goethe University
Curated by ChEMBL
Affinity DataKi: 1.26nMAssay Description:Displacement of [3H]N-alpha-methylhistamine from histamine H3 receptor in rat striatal membraneMore data for this Ligand-Target Pair
Affinity DataKi: 1.40nMAssay Description:Binding affinity to human histamine H3 receptorMore data for this Ligand-Target Pair
Affinity DataKi: 9.24nMAssay Description:Binding affinity to human histamine H3 receptorMore data for this Ligand-Target Pair
TargetHistamine H4 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research and Development
Curated by PDSP Ki Database
Johnson & Johnson Pharmaceutical Research and Development
Curated by PDSP Ki Database
TargetHistamine H2 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research and Development
Curated by PDSP Ki Database
Johnson & Johnson Pharmaceutical Research and Development
Curated by PDSP Ki Database
Affinity DataIC50: 0.530nMAssay Description:Inhibition of histone H3 receptorMore data for this Ligand-Target Pair
TargetAcetylcholinesterase(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development
Curated by ChEMBL
Johnson & Johnson Pharmaceutical Research And Development
Curated by ChEMBL
Affinity DataIC50: 3.20E+3nMAssay Description:Inhibition of AChEMore data for this Ligand-Target Pair