BDBM25428 4-[3-(4-hydroxybutyl)-4,4-dimethyl-2,5-dioxoimidazolidin-1-yl]-2-(trifluoromethyl)benzonitrile::CHEMBL9337::RU-58841

SMILES CC1(C)N(CCCCO)C(=O)N(C1=O)c1ccc(C#N)c(c1)C(F)(F)F

InChI Key InChIKey=ARBYGDBJECGMGA-UHFFFAOYSA-N

Data  3 KI  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 25428   

TargetAndrogen receptor(Rattus norvegicus (Rat))
The University Of Michigan Medical School

Curated by ChEMBL
LigandPNGBDBM25428(4-[3-(4-hydroxybutyl)-4,4-dimethyl-2,5-dioxoimidaz...)
Affinity DataKi:  26nMAssay Description:Inhibition of rat prostate cytosolic androgen receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Rattus norvegicus (Rat))
The University Of Michigan Medical School

Curated by ChEMBL
LigandPNGBDBM25428(4-[3-(4-hydroxybutyl)-4,4-dimethyl-2,5-dioxoimidaz...)
Affinity DataKi:  26nMAssay Description:Binding affinity against rat prostate cytosolic Androgen receptor using [3H]mibolerone as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Rattus norvegicus (Rat))
The University Of Michigan Medical School

Curated by ChEMBL
LigandPNGBDBM25428(4-[3-(4-hydroxybutyl)-4,4-dimethyl-2,5-dioxoimidaz...)
Affinity DataKi:  26nMAssay Description:Inhibition of [3H]mibolerone binding to cytosolic androgen receptor of rat ventral prostateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM25428(4-[3-(4-hydroxybutyl)-4,4-dimethyl-2,5-dioxoimidaz...)
Affinity DataIC50:  16nMAssay Description:Displacement of [3H]DHT from human cloned androgen receptor expressed in insect Sf9 cell systemMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM25428(4-[3-(4-hydroxybutyl)-4,4-dimethyl-2,5-dioxoimidaz...)
Affinity DataIC50:  15.9nMAssay Description:Displacement of [3H]dihydrotestosterone from human androgen receptor expressed in Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM25428(4-[3-(4-hydroxybutyl)-4,4-dimethyl-2,5-dioxoimidaz...)
Affinity DataIC50:  32nMAssay Description:Antagonist activity at human androgen receptor expressed in human MDA-MB-231 cells assessed as inhibition of DHT-induced responseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM25428(4-[3-(4-hydroxybutyl)-4,4-dimethyl-2,5-dioxoimidaz...)
Affinity DataIC50:  16nMpH: 7.4 T: 2°CAssay Description:The competitive radio-ligand binding analysis was performed on human AR extracts from transfected Sf9 cells in the presence or absence of differing c...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM25428(4-[3-(4-hydroxybutyl)-4,4-dimethyl-2,5-dioxoimidaz...)
Affinity DataIC50:  31.1nMAssay Description:Antagonist activity at human androgen receptor expressed in MDA-MB-453 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed