BDBM10452 Bivalent 4-Aminoquinoline 9f::N,N-di-4-Quinolyl-1,7-diaminoheptane dihydrochloride::N-[7-(quinolin-4-ylamino)heptyl]quinolin-4-amine dihydrochloride

SMILES C(CCCNc1ccnc2ccccc12)CCCNc1ccnc2ccccc12

InChI Key InChIKey=OQGAVEZMVJJWSH-UHFFFAOYSA-N

Data  8 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 10452   

TargetAlpha-1A adrenergic receptor(Homo sapiens (Human))
Unsw Australia

Curated by ChEMBL
LigandPNGBDBM10452(Bivalent 4-Aminoquinoline 9f | N,N-di-4-Quinolyl-1...)
Affinity DataKi:  126nMAssay Description:Binding affinity to human alpha1A adrenergic receptor transfected in COS1 cells assessed as compound required to occupy 50% of receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A adrenergic receptor(Homo sapiens (Human))
Unsw Australia

Curated by ChEMBL
LigandPNGBDBM10452(Bivalent 4-Aminoquinoline 9f | N,N-di-4-Quinolyl-1...)
Affinity DataKi:  126nMAssay Description:Displacement of [3H]-prazosin from human alpha1A adrenergic receptor transfected in COS1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1B adrenergic receptor(Homo sapiens (Human))
Unsw Australia

Curated by ChEMBL
LigandPNGBDBM10452(Bivalent 4-Aminoquinoline 9f | N,N-di-4-Quinolyl-1...)
Affinity DataKi:  148nMAssay Description:Binding affinity to human alpha1B adrenergic receptor transfected in COS1 cells assessed as compound required to occupy 50% of receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1B adrenergic receptor(Homo sapiens (Human))
Unsw Australia

Curated by ChEMBL
LigandPNGBDBM10452(Bivalent 4-Aminoquinoline 9f | N,N-di-4-Quinolyl-1...)
Affinity DataKi:  148nMAssay Description:Displacement of [3H]-prazosin from human alpha1B adrenergic receptor transfected in COS1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1D adrenergic receptor(Homo sapiens (Human))
Unsw Australia

Curated by ChEMBL
LigandPNGBDBM10452(Bivalent 4-Aminoquinoline 9f | N,N-di-4-Quinolyl-1...)
Affinity DataKi:  309nMAssay Description:Displacement of [3H]-prazosin from human alpha1D adrenergic receptor transfected in COS1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1D adrenergic receptor(Homo sapiens (Human))
Unsw Australia

Curated by ChEMBL
LigandPNGBDBM10452(Bivalent 4-Aminoquinoline 9f | N,N-di-4-Quinolyl-1...)
Affinity DataKi:  309nMAssay Description:Binding affinity to human alpha1D adrenergic receptor transfected in COS1 cells assessed as compound required to occupy 50% of receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Unsw Australia

Curated by ChEMBL
LigandPNGBDBM10452(Bivalent 4-Aminoquinoline 9f | N,N-di-4-Quinolyl-1...)
Affinity DataKi:  832nMAssay Description:Displacement of [3H]8-OH-DPAT from human 5HT1A receptor transfected in COS1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Unsw Australia

Curated by ChEMBL
LigandPNGBDBM10452(Bivalent 4-Aminoquinoline 9f | N,N-di-4-Quinolyl-1...)
Affinity DataKi:  832nMAssay Description:Binding affinity to human 5HT1A receptor transfected in COS1 cells assessed as compound required to occupy 50% of receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarboxylic ester hydrolase(Rattus norvegicus (rat))
Hong Kong University of Science and Technology

LigandPNGBDBM10452(Bivalent 4-Aminoquinoline 9f | N,N-di-4-Quinolyl-1...)
Affinity DataIC50:  1.80E+3nMAssay Description:The cholinesterase assays were performed using colorimetric method reported by Ellman. Enzyme activity was determined by measuring the absorbance at...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Rattus norvegicus (rat))
Hong Kong University of Science and Technology

LigandPNGBDBM10452(Bivalent 4-Aminoquinoline 9f | N,N-di-4-Quinolyl-1...)
Affinity DataIC50:  87.8nMpH: 7.4 T: 2°CAssay Description:The cholinesterase assays were performed using colorimetric method reported by Ellman. Enzyme activity was determined by measuring the absorbance at...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed