BDBM10512 CHEMBL194823::N-{3-[(6-chloro-1,2,3,4-tetrahydroacridin-9-yl)amino]propyl}-5-(1,2-dithiolan-3-yl)pentanamide::tacrine-lipoic acid hybrid 7
SMILES Clc1ccc2c(NCCCNC(=O)CCCCC3CCSS3)c3CCCCc3nc2c1
InChI Key InChIKey=QVGXTQPZHCDXRZ-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 12 hits for monomerid = 10512
Affinity DataKi: 155nM ΔG°: -9.66kcal/mole IC50: 0.253nMpH: 8.0 T: 2°CAssay Description:The cholinesterase assays were performed using colorimetric method reported by Ellman. Enzyme activity was determined by measuring the absorbance at...More data for this Ligand-Target Pair
Affinity DataIC50: 0.25nMAssay Description:Inhibition of AChE (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 4.50E+4nMAssay Description:Inhibition of AChE (unknown origin)-mediated amyloid beta aggregationMore data for this Ligand-Target Pair
Affinity DataIC50: 0.25nMAssay Description:Inhibition of human AchEMore data for this Ligand-Target Pair
Affinity DataIC50: 4.50E+4nMAssay Description:Inhibition of beta amyloid (unknown origin) depositionMore data for this Ligand-Target Pair
Affinity DataIC50: 11nMAssay Description:Inhibition of human recombinant BChE by Ellman's methodMore data for this Ligand-Target Pair
Affinity DataIC50: 0.253nMAssay Description:Inhibition of human serum recombinant AChE after 20 mins using acetylthiocholine iodide as a substrate by Ellman's assayMore data for this Ligand-Target Pair
Affinity DataIC50: 10.8nMAssay Description:Inhibition of human serum recombinant BChE after 20 mins using butyrylthiocholine iodide as a substrate by Ellman's assayMore data for this Ligand-Target Pair
Affinity DataIC50: 4.50E+4nMAssay Description:Inhibition of human AchE-induced amyloid beta aggregationMore data for this Ligand-Target Pair
Affinity DataIC50: 0.25nMAssay Description:Inhibition of AChE (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 10.8nMpH: 8.0 T: 2°CAssay Description:The cholinesterase assays were performed using colorimetric method reported by Ellman. Enzyme activity was determined by measuring the absorbance at...More data for this Ligand-Target Pair
Affinity DataIC50: 0.253nMAssay Description:Inhibition of human recombinant AChE by Ellman's methodMore data for this Ligand-Target Pair