BDBM115911 US8633183, E-55

SMILES CCc1ncnc(-c2ccc(C(=O)N3CC[C@@H](C3)N(C)C)c(OC)c2)c1C#Cc1ccc(N)nc1

InChI Key InChIKey=YSQGOGPDEDVEFK-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 115911   

TargetSerine/threonine-protein kinase mTOR(Human)
Boehringer Ingelheim International

US Patent
LigandChemical structure of BindingDB Monomer ID 115911BDBM115911(US8633183, E-55)
Affinity DataIC50: 62.0nMAssay Description:The mTOR kinase TR-FRET assay utilizes a physiologically relevant protein substrate for mTOR (4E-BP1, labeled with an acceptor fluorophore (Green Flu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2014
Entry Details
US Patent

TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Human)
Boehringer Ingelheim International

US Patent
LigandChemical structure of BindingDB Monomer ID 115911BDBM115911(US8633183, E-55)
Affinity DataIC50: 148nMAssay Description:PI3Kalpha assay described herein provides IC50 values indicating the activity of the compounds inhibiting PI3 kinase alpha activity Inhibition of PI3...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2014
Entry Details
US Patent