BDBM116314 US8637526, 240
SMILES Cc1cc(NC(=O)c2cnn3ccc(Nc4cccc(c4)C(F)(F)F)nc23)on1
InChI Key InChIKey=GZFDPJXFJXZZAQ-UHFFFAOYSA-N
Data 4 KI
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 4 hits for monomerid = 116314
Affinity DataKi: 3.20nM ΔG°: -11.5kcal/molepH: 7.2 T: 2°CAssay Description:To determine the inhibition constants (Ki), compounds were diluted serially in DMSO and added to 50 kinase reactions containing 0.2 nM purified JAK2 ...More data for this Ligand-Target Pair
Affinity DataKi: 36nMpH: 7.2Assay Description:To determine inhibition constants (Ki), compounds were diluted serially in DMSO and added to 50 uL kinase reactions containing 1.5 nM JAK1, 0.2 nM pu...More data for this Ligand-Target Pair
Affinity DataKi: 62.4nMpH: 7.2Assay Description:To determine inhibition constants (Ki), compounds were diluted serially in DMSO and added to 50 uL kinase reactions containing 1.5 nM JAK1, 0.2 nM pu...More data for this Ligand-Target Pair
Affinity DataKi: 95.1nM ΔG°: -9.48kcal/molepH: 7.2 T: 2°CAssay Description:To determine inhibition constants (Ki), compounds were diluted serially in DMSO and added to 50 uL kinase reactions containing 5 nM purified JAK3 enz...More data for this Ligand-Target Pair