BDBM118293 US8653092, 61

SMILES COc1ncc(cc1C(F)(F)F)N1CCc2ncnc(O[C@H]3CCN(C3)C(=O)C3CCOCC3)c2C1

InChI Key InChIKey=VKHGYVPRHIWYCB-KRWDZBQOSA-N

Data  10 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 118293   

LigandPNGBDBM118293(US8653092, 61)
Affinity DataIC50:  589nMAssay Description:Test of Lipid Kinase Activity: The kinase reaction is performed in a final volume of 50 μl per well of a half area COSTAR, 96 well plate. The fi...More data for this Ligand-Target Pair
In DepthDetails US Patent
LigandPNGBDBM118293(US8653092, 61)
Affinity DataIC50:  12nMAssay Description:Test of Lipid Kinase Activity: The kinase reaction is performed in a final volume of 50 μl per well of a half area COSTAR, 96 well plate. The fi...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM118293(US8653092, 61)
Affinity DataIC50:  1.33E+3nMAssay Description:Negative logarithm of the molar concentration of delta receptor was determined in mouse vas deferensMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM118293(US8653092, 61)
Affinity DataIC50:  28nMAssay Description:Inhibition of PI3Kdelta (unknown origin) using phosphatidyl inositol as substrate measured after 60 mins by Alexa Fluor647-labelled ADP tracer based ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM118293(US8653092, 61)
Affinity DataIC50: >9.10E+3nMAssay Description:Inhibition of PI3Kgamma (unknown origin) using phosphatidyl inositol as substrate measured after 30 mins by Alexa Fluor647-labelled ADP tracer based ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM118293(US8653092, 61)
Affinity DataIC50:  3.55E+3nMAssay Description:Negative logarithm of the molar concentration of delta receptor was determined in mouse vas deferensMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM118293(US8653092, 61)
Affinity DataIC50:  37nMAssay Description:Inhibition of recombinant human myristoylated PI3Kdelta catalytic domain expressed in Rat1 cells assessed as reduction in Akt phosphorylation at Ser4...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Mus musculus (Mouse))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM118293(US8653092, 61)
Affinity DataIC50:  84nMAssay Description:Inhibition of PI3Kdelta in Balb/c mouse splenocytes assessed as reduction in anti-IgM stimulated CD86 expression pretreated for 1 hr followed by anti...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM118293(US8653092, 61)
Affinity DataIC50:  1.33E+3nMAssay Description:Inhibition of recombinant human myristoylated PI3Kbeta catalytic domain expressed in Rat1 cells assessed as reduction in Akt phosphorylation at Ser47...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM118293(US8653092, 61)
Affinity DataIC50:  590nMAssay Description:Inhibition of recombinant PI3Kalpha (unknown origin) using phosphatidyl inositol/n-Octyl-glucoside as substrate measured after 30 mins by KinaseGlo a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed