BDBM119386 US8669361, 113::US9573943, Example 113

SMILES Cn1ncc(NC(=O)c2nc(sc2N)-c2c(F)cccc2F)c1N1CCCC(N)CC1

InChI Key InChIKey=JEVIKKKBDOXJFA-UHFFFAOYSA-N

Data  6 KI

PDB links: 1 PDB ID matches this monomer.

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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 119386   

TargetSerine/threonine-protein kinase pim-3(Homo sapiens (Human))
F. Hoffmann-La Roche

US Patent
LigandPNGBDBM119386(US8669361, 113 | US9573943, Example 113)
Affinity DataKi:  0.0220nMpH: 7.2Assay Description:PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J. F., a...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSerine/threonine-protein kinase pim-3(Homo sapiens (Human))
F. Hoffmann-La Roche

US Patent
LigandPNGBDBM119386(US8669361, 113 | US9573943, Example 113)
Affinity DataKi:  0.0220nM ΔG°:  -14.5kcal/molepH: 7.2 T: 2°CAssay Description:PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J. F., a...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM119386(US8669361, 113 | US9573943, Example 113)
Affinity DataKi:  0.0270nM ΔG°:  -14.4kcal/molepH: 7.2 T: 2°CAssay Description:PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J. F., a...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM119386(US8669361, 113 | US9573943, Example 113)
Affinity DataKi:  0.0270nMpH: 7.2Assay Description:PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J. F., a...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSerine/threonine-protein kinase pim-2(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM119386(US8669361, 113 | US9573943, Example 113)
Affinity DataKi:  0.316nM ΔG°:  -13.0kcal/molepH: 7.2 T: 2°CAssay Description:PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J. F., a...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSerine/threonine-protein kinase pim-2(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM119386(US8669361, 113 | US9573943, Example 113)
Affinity DataKi:  0.316nMpH: 7.2Assay Description:PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J. F., a...More data for this Ligand-Target Pair
In DepthDetails US Patent