BDBM127388 US8791131, 150

SMILES CN(C)c1ccc(cn1)-c1ccc2ncc3n(C)c(=O)n(C4CCN(CC(F)(F)F)CC4)c3c2n1

InChI Key InChIKey=WAMJHIPLMJJLBJ-UHFFFAOYSA-N

Data  2 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 127388   

LigandChemical structure of BindingDB Monomer ID 127388BDBM127388(US8791131, 150)
Affinity DataKi:  8.78nM ΔG°:  -11.0kcal/molepH: 7.4 T: 2°CAssay Description:Compounds of the present invention were evaluated for potency against PI3-Kalpha using an in vitro kinase assay. PI3-Kalpha activity is measured in v...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2014
Entry Details
US Patent

TargetSerine/threonine-protein kinase mTOR(Human)
Pfizer

US Patent
LigandChemical structure of BindingDB Monomer ID 127388BDBM127388(US8791131, 150)
Affinity DataKi:  12.5nM ΔG°:  -10.8kcal/molepH: 7.5 T: 2°CAssay Description:Compounds of the present invention were evaluated for potency against mTOR using an in vitro kinase assay. mTOR activity is measured in vitro by dete...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2014
Entry Details
US Patent