BDBM127458 US8791131, 232

SMILES C[C@H](CO)n1c2c(cnc3ccc(nc23)-c2cnn(C)c2)n(C)c1=O

InChI Key InChIKey=UEZNYVYALSSRDB-UHFFFAOYSA-N

Data  2 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 127458   

LigandChemical structure of BindingDB Monomer ID 127458BDBM127458(US8791131, 232)
Affinity DataKi:  143nM ΔG°:  -9.33kcal/molepH: 7.4 T: 2°CAssay Description:Compounds of the present invention were evaluated for potency against PI3-Kalpha using an in vitro kinase assay. PI3-Kalpha activity is measured in v...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2014
Entry Details
US Patent

TargetSerine/threonine-protein kinase mTOR(Human)
Pfizer

US Patent
LigandChemical structure of BindingDB Monomer ID 127458BDBM127458(US8791131, 232)
Affinity DataKi:  521nM ΔG°:  -8.57kcal/molepH: 7.5 T: 2°CAssay Description:Compounds of the present invention were evaluated for potency against mTOR using an in vitro kinase assay. mTOR activity is measured in vitro by dete...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2014
Entry Details
US Patent