BDBM134608 US8846698, 71

SMILES CC(C)n1cc(C(=O)c2cncc(NC(=O)Cc3ccc(cc3)C#N)c2)c2cncnc12

InChI Key InChIKey=ZJYCGJNMKTVBQP-UHFFFAOYSA-N

Data  1 KI  3 IC50

PDB links: 1 PDB ID matches this monomer.

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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 134608   

TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM134608(US8846698, 71)
Affinity DataKi:  7.10E+3nMAssay Description:Inhibition of dofetilide binding to human ERGMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBDNF/NT-3 growth factors receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM134608(US8846698, 71)
Affinity DataIC50:  42nMAssay Description:Inhibition of human TrkB expressed in human U2OS cells pre-incubated 30 mins before neurotrophin addition and measured after 2 hrs by luminescence ba...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM134608(US8846698, 71)
Affinity DataIC50:  135nMAssay Description:Isolated TRK Enzyme assays use the HTRF KinEASE-TK kit (Cisbio Cat# 62TK0PEJ) with recombinant His-tagged cytoplasmic domains of each TRK receptor so...More data for this Ligand-Target Pair
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM134608(US8846698, 71)
Affinity DataIC50:  62nMAssay Description:Inhibition of human TrkA expressed in human U2OS cells pre-incubated 30 mins before neurotrophin addition and measured after 2 hrs by luminescence ba...More data for this Ligand-Target Pair