BDBM138363 US10278929, Compound Ro-41-0960::US11337935, Compound Ro-41-0960::US8877795, Ro 41-0960
SMILES Oc1cc(cc(c1O)[N+]([O-])=O)C(=O)c1ccccc1F
InChI Key InChIKey=RQPAUNZYTYHKHA-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 4 hits for monomerid = 138363
TargetTransthyretin(Homo sapiens (Human))
The Board of Trustees of The Leland Stanford Junior University
US Patent
The Board of Trustees of The Leland Stanford Junior University
US Patent
Affinity DataIC50: 755nMAssay Description:The FP assay was then adapted for HTS and used to screen ~120,000 small molecule library for compounds that displaced probe 5 from the T4 binding of ...More data for this Ligand-Target Pair
TargetTransthyretin(Homo sapiens (Human))
The Board of Trustees of The Leland Stanford Junior University
US Patent
The Board of Trustees of The Leland Stanford Junior University
US Patent
Affinity DataIC50: 755nMAssay Description:Table 3: The FP assay was then adapted for HTS and used to screen 120,000 small molecule library for compounds that displaced probe 5 from the T4 bin...More data for this Ligand-Target Pair
TargetTransthyretin(Homo sapiens (Human))
The Board of Trustees of The Leland Stanford Junior University
US Patent
The Board of Trustees of The Leland Stanford Junior University
US Patent
Affinity DataKd: 184nMAssay Description:Dissociation Constants (Kd) associated with the binding of ligands to TTR are expressed in nM. Thermodynamic Binding Parameters associated with ligan...More data for this Ligand-Target Pair
TargetTransthyretin(Homo sapiens (Human))
The Board of Trustees of The Leland Stanford Junior University
US Patent
The Board of Trustees of The Leland Stanford Junior University
US Patent
Affinity DataIC50: 755nMAssay Description:The FP assay was then adapted for HTS and used to screen a ˜120,000 member small molecule library for compounds that displaced the FP probe from the ...More data for this Ligand-Target Pair
Activity Spreadsheet -- ITC Data from BindingDB
Found 1 hit for monomerid = 138363
ITC DataΔG°: -9.17kcal/mole −TΔS°: 4.27kcal/mole ΔH°: -13.5kcal/mole logk: 5.34E+6
pH: 7.5 T: 25.00°C
pH: 7.5 T: 25.00°C