BindingDB BDBM14775 3-(cyclopentyloxy)-N-(3,5-dichloropyridin-4-yl)-4-methoxybenzamide::3-cyclopentyloxy-N-(3,5-dichloropyridin-4-yl)-4-methoxy-benzamide::CHEMBL42126::Cpodpmb::Piclamilast::RPR-73401

BDBM14775 3-(cyclopentyloxy)-N-(3,5-dichloropyridin-4-yl)-4-methoxybenzamide::3-cyclopentyloxy-N-(3,5-dichloropyridin-4-yl)-4-methoxy-benzamide::CHEMBL42126::Cpodpmb::Piclamilast::RPR-73401

SMILES COc1ccc(cc1OC1CCCC1)C(=O)Nc1c(Cl)cncc1Cl

InChI Key InChIKey=RRRUXBQSQLKHEL-UHFFFAOYSA-N

Data 11 KI 39 IC50

PDB links: 3 PDB IDs match this monomer.

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 14775

Isoform 4 of Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A (PDE11A1) 35-489](Homo sapiens (Human))
Plexxikon

BDBM14775(3-(cyclopentyloxy)-N-(3,5-dichloropyridin-4-yl)-4-...)

IC50: 1.60E+3nMAssay Description:Phosphodiesterase activities were assayed in the presence of inhibitor compounds. Measurement takes advantage of the selective binding of 5-AMP or 5-...More data for this Ligand-Target Pair

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cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A [432-779](Homo sapiens (Human))
Plexxikon

BDBM14775(3-(cyclopentyloxy)-N-(3,5-dichloropyridin-4-yl)-4-...)

IC50: 2.10E+4nMAssay Description:Phosphodiesterase activities were assayed in the presence of inhibitor compounds. Measurement takes advantage of the selective binding of 5-AMP or 5-...More data for this Ligand-Target Pair

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High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A [226-593](Homo sapiens (Human))
Plexxikon

BDBM14775(3-(cyclopentyloxy)-N-(3,5-dichloropyridin-4-yl)-4-...)

IC50: >2.00E+5nMAssay Description:Phosphodiesterase activities were assayed in the presence of inhibitor compounds. Measurement takes advantage of the selective binding of 5-AMP or 5-...More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway
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High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A(Homo sapiens (Human))
Plexxikon

BDBM14775(3-(cyclopentyloxy)-N-(3,5-dichloropyridin-4-yl)-4-...)

PDB MMDB Reactome pathway KEGG
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cAMP-specific 3',5'-cyclic phosphodiesterase 7B [91-450](Homo sapiens (Human))
Plexxikon

BDBM14775(3-(cyclopentyloxy)-N-(3,5-dichloropyridin-4-yl)-4-...)

IC50: 8.80E+3nMAssay Description:Phosphodiesterase activities were assayed in the presence of inhibitor compounds. Measurement takes advantage of the selective binding of 5-AMP or 5-...More data for this Ligand-Target Pair

Reactome pathway KEGG
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cGMP-specific 3',5'-cyclic phosphodiesterase [531-875](Homo sapiens (Human))
Plexxikon

BDBM14775(3-(cyclopentyloxy)-N-(3,5-dichloropyridin-4-yl)-4-...)

IC50: 3.50E+3nMAssay Description:Phosphodiesterase activities were assayed in the presence of inhibitor compounds. Measurement takes advantage of the selective binding of 5-AMP or 5-...More data for this Ligand-Target Pair

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cAMP-specific 3',5'-cyclic phosphodiesterase 4D [372-376,381-715,S375G,I381V,S383G,G384S,V385H,K386M)(Homo sapiens (Human))
Plexxikon

BDBM14775(3-(cyclopentyloxy)-N-(3,5-dichloropyridin-4-yl)-4-...)

IC50: 0.0210nMAssay Description:Phosphodiesterase activities were assayed in the presence of inhibitor compounds. Measurement takes advantage of the selective binding of 5-AMP or 5-...More data for this Ligand-Target Pair

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3D Structure (crystal)

cAMP-specific 3',5'-cyclic phosphodiesterase 4B [316-320,321-700,S319G,N320S,N321H,T322M](Homo sapiens (Human))
Plexxikon

BDBM14775(3-(cyclopentyloxy)-N-(3,5-dichloropyridin-4-yl)-4-...)

IC50: 0.0410nMAssay Description:Phosphodiesterase activities were assayed in the presence of inhibitor compounds. Measurement takes advantage of the selective binding of 5-AMP or 5-...More data for this Ligand-Target Pair

PDB MMDB
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3D Structure (crystal)

cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B [650-1084](Homo sapiens (Human))
Plexxikon

BDBM14775(3-(cyclopentyloxy)-N-(3,5-dichloropyridin-4-yl)-4-...)

IC50: 1.10E+4nMAssay Description:Phosphodiesterase activities were assayed in the presence of inhibitor compounds. Measurement takes advantage of the selective binding of 5-AMP or 5-...More data for this Ligand-Target Pair

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Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B(Homo sapiens (Human))
Plexxikon

BDBM14775(3-(cyclopentyloxy)-N-(3,5-dichloropyridin-4-yl)-4-...)

IC50: 6.80E+4nMpH: 7.5 T: 2°CAssay Description:Phosphodiesterase activities were assayed in the presence of inhibitor compounds. Measurement takes advantage of the selective binding of 5-AMP or 5-...More data for this Ligand-Target Pair

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cGMP-dependent 3',5'-cyclic phosphodiesterase [574-941](Homo sapiens (Human))
Plexxikon

BDBM14775(3-(cyclopentyloxy)-N-(3,5-dichloropyridin-4-yl)-4-...)

IC50: 5.40E+4nMAssay Description:Phosphodiesterase activities were assayed in the presence of inhibitor compounds. Measurement takes advantage of the selective binding of 5-AMP or 5-...More data for this Ligand-Target Pair

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Filter my 50 hits

Targets 17▿
- cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D 18
- cAMP-specific 3',5'-cyclic phosphodiesterase 4B 10
- cAMP-specific 3',5'-cyclic phosphodiesterase 4D 6
- cAMP-specific 3',5'-cyclic phosphodiesterase 4A 2
- cAMP-specific 3',5'-cyclic phosphodiesterase 4C 2
- cAMP-specific 3',5'-cyclic phosphodiesterase 4D [372-376,381-715,S375G,I381V,S383G,G384S,V385H,K386M) 1
- cGMP-specific 3',5'-cyclic phosphodiesterase [531-875] 1
- cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A [432-779] 1
- cAMP-specific 3',5'-cyclic phosphodiesterase 7B [91-450] 1
- Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B 1
- High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A 1
- 3',5'-cyclic-AMP phosphodiesterase 1
- cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B [650-1084] 1
- cGMP-dependent 3',5'-cyclic phosphodiesterase [574-941] 1
- cAMP-specific 3',5'-cyclic phosphodiesterase 4B [316-320,321-700,S319G,N320S,N321H,T322M] 1
- Isoform 4 of Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A (PDE11A1) 35-489] 1
- High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A [226-593] 1
Publications 19▿
- Structure 12: 2233-47 (2004) 11
- J Med Chem 41: 266-70 (1998) 4
- J Med Chem 50: 344-9 (2007) 4
- J Med Chem 59: 7029-65 (2016) 4
- Bioorg Med Chem Lett 8: 2737-42 (1998) 3
- Bioorg Med Chem Lett 13: 2347-50 (2003) 2
- J Med Chem 41: 4216-23 (1998) 2
- J Med Chem 63: 10594-10617 (2020) 2
- Bioorg Med Chem Lett 8: 1867-72 (1998) 2
- J Pharmacol Exp Ther 305: 565-72 (2003) 2
- Bioorg Med Chem Lett 10: 2235-8 (2000) 2
- Bioorg Med Chem 18: 2204-18 (2010) 2
- Bioorg Med Chem Lett 12: 5-8 (2002) 2
- Bioorg Med Chem Lett 12: 653-8 (2002) 2
- Bioorg Med Chem Lett 8: 3053-8 (1998) 2
- Bioorg Med Chem Lett 11: 33-7 (2001) 1
- Bioorg Med Chem Lett 20: 2928-32 (2010) 1
- J Med Chem 41: 2268-77 (1998) 1
- J Med Chem 37: 1696-703 (1994) 1
Institutions 14▿
- Plexxikon 11
- Pfizer 9
- Zambon Group 5
- Vrije Universiteit Amsterdam 4
- Rh£Ne-Poulenc Rorer Central Research 4
- Rh£Ne-Poulenc Rorer 3
- Janssen-Cilag 2
- University Of Tennessee 2
- Tanabe Seiyaku 2
- Sichuan Academy Of Medical Science & Sichuan Provincial People'S Hospital 2
- King'S College London 2
- Sw 8 Rh£Ne-Poulenc Rorer Central Research 2
- RhôNe-Poulenc Rorer 1
- Kalypsys 1
Affinity: 0.021 to 2.0E+5 nM▿
- Ki 11
- IC50 39
- Affinity ≤ nM
Xtal structures: 1
Docked structures: 2
Catalog Cmpds: 1