BDBM150836 US8981106, 25::USRE47267, Compound 25

SMILES OC(=O)c1cccc(CSc2ccc(cn2)C(=O)Nc2ccc(F)cc2)c1

InChI Key InChIKey=DGMNFRFRKNNMQE-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 150836   

TargetC-X-C chemokine receptor type 2(Homo sapiens (Human))
Syntrix Biosystems

US Patent
LigandPNGBDBM150836(US8981106, 25 | USRE47267, Compound 25)
Affinity DataIC50:  2.12E+3nMT: 2°CAssay Description:An in vitro assay showed inhibition of CXCR2-mediated intracellular calcium release. Briefly, human neutrophils were suspended in HBSS- (without Ca2+...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetC-X-C chemokine receptor type 2(Homo sapiens (Human))
Syntrix Biosystems

US Patent
LigandPNGBDBM150836(US8981106, 25 | USRE47267, Compound 25)
Affinity DataIC50:  2.12E+3nMAssay Description:The assay is a Ca2+ mobilization assay that measures changes in intracellular Ca2+ with a FlexStation II scanning fluorometer using a FLIPR-3 Calcium...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetC-X-C chemokine receptor type 2(Homo sapiens (Human))
Syntrix Biosystems

US Patent
LigandPNGBDBM150836(US8981106, 25 | USRE47267, Compound 25)
Affinity DataIC50:  2.12E+3nMAssay Description:Antagonist activity at CXCR2 in human PMNs assessed as inhibition of CXCL1-induced intracellular Ca2+ release by fluorescence based calcium flux assa...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed