BDBM15161 1-[1-({4-[5-(2-methylpropyl)-6-oxo-3-phenyl-1,6-dihydropyrazin-2-yl]phenyl}methyl)piperidin-4-yl]-2,3-dihydro-1H-1,3-benzodiazol-2-one::pyrazinone 14f

SMILES CC(C)Cc1nc(-c2ccccc2)c([nH]c1=O)-c1ccc(CN2CCC(CC2)n2c3ccccc3[nH]c2=O)cc1

InChI Key InChIKey=RJPLOWNWNWVHLW-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 15161   

TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Merck Research Laboratories

LigandPNGBDBM15161(1-[1-({4-[5-(2-methylpropyl)-6-oxo-3-phenyl-1,6-di...)
Affinity DataIC50:  2.12E+4nMpH: 7.5 T: 2°CAssay Description:Purified recombinant human Akt1, Akt2, and Akt3 proteins were monitored for kinase activity in the presence or absence of Akt inhibitors in a 96-well...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-gamma serine/threonine-protein kinase(Homo sapiens (Human))
Merck Research Laboratories

LigandPNGBDBM15161(1-[1-({4-[5-(2-methylpropyl)-6-oxo-3-phenyl-1,6-di...)
Affinity DataIC50:  2.19E+4nMAssay Description:Purified recombinant human Akt1, Akt2, and Akt3 proteins were monitored for kinase activity in the presence or absence of Akt inhibitors in a 96-well...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-beta serine/threonine-protein kinase(Homo sapiens (Human))
Merck Research Laboratories

LigandPNGBDBM15161(1-[1-({4-[5-(2-methylpropyl)-6-oxo-3-phenyl-1,6-di...)
Affinity DataIC50:  325nMAssay Description:Purified recombinant human Akt1, Akt2, and Akt3 proteins were monitored for kinase activity in the presence or absence of Akt inhibitors in a 96-well...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed