BDBM158485 US10383835, Compound 2228::US9029401, 2227

SMILES CNC(=O)c1ccc(O[C@H]2CCC(CC2)NC(=O)Nc2ccc(OC(F)(F)F)cc2)cc1

InChI Key InChIKey=JNPWHXLRBKEIPP-OZEGIUPXSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 158485   

TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
The Regents Of The University Of California

US Patent
LigandPNGBDBM158485(US10383835, Compound 2228 | US9029401, 2227)
Affinity DataIC50:  0.5nMAssay Description:See reference (Jones, P. D.; Wolf, N. M.; Morisseau, C.; Whetstone, P.; Hock, B.; Hammock, B. D. Anal. Biochem. 343:66-75; 2005) for sEH assay.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
The Regents Of The University Of California

US Patent
LigandPNGBDBM158485(US10383835, Compound 2228 | US9029401, 2227)
Affinity DataIC50:  340nMpH: 7.5Assay Description:Inhibitor Concentration at 50% enzyme inhibition (IC50) values were calculated by quantifying the end-point ADP production from each kinase reaction ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetEpoxide hydrolase 1(Felis catus (Cat) (Felis silvestris catus))
The Regents Of The University Of California

US Patent
LigandPNGBDBM158485(US10383835, Compound 2228 | US9029401, 2227)
Affinity DataIC50:  2nMAssay Description:The enzyme also can be detected based on the binding of specific ligands to the catalytic site which either immobilize the enzyme or label it with a ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetEpoxide hydrolase(Equus caballus (Horse))
The Regents Of The University Of California

US Patent
LigandPNGBDBM158485(US10383835, Compound 2228 | US9029401, 2227)
Affinity DataIC50:  1nMAssay Description:The enzyme also can be detected based on the binding of specific ligands to the catalytic site which either immobilize the enzyme or label it with a ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetEpoxide hydrolase(Ovis aries (Sheep))
The Regents Of The University Of California

US Patent
LigandPNGBDBM158485(US10383835, Compound 2228 | US9029401, 2227)
Affinity DataIC50:  1nMAssay Description:The enzyme also can be detected based on the binding of specific ligands to the catalytic site which either immobilize the enzyme or label it with a ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSerine/threonine-protein kinase B-raf [V600E](Homo sapiens (Human))
The Regents Of The University Of California

US Patent
LigandPNGBDBM158485(US10383835, Compound 2228 | US9029401, 2227)
Affinity DataIC50: >1.00E+4nMpH: 7.5Assay Description:Inhibitor Concentration at 50% enzyme inhibition (IC50) values were calculated by quantifying the end-point ADP production from each kinase reaction ...More data for this Ligand-Target Pair
In DepthDetails US Patent