BDBM166686 2-methyl-5-(propan-2-yl)cyclohexa-2,5-diene-1,4-dione (F8)

SMILES CC(C)C1=CC(=O)C(C)=CC1=O

InChI Key InChIKey=KEQHJBNSCLWCAE-UHFFFAOYSA-N

Data  5 IC50

PDB links: 1 PDB ID matches this monomer.

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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 166686   

TargetCaspase-1(Homo sapiens (Human))
Depaul University

LigandPNGBDBM166686(2-methyl-5-(propan-2-yl)cyclohexa-2,5-diene-1,4-di...)
Affinity DataIC50:  1.08E+3nMpH: 7.5 T: 2°CAssay Description:All assays were performed at 100 µL total volume in triplicate and monitored for 60 minutes at room temperature in a 96-well plate format in HEPES Bu...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase PLK1(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM166686(2-methyl-5-(propan-2-yl)cyclohexa-2,5-diene-1,4-di...)
Affinity DataIC50:  2.18E+3nMAssay Description:Inhibition of recombinant Plk1 (unknown origin) preincubated for 30 mins before recombinant Cdc25C substrate addition by ADP-Glo kinase assayMore data for this Ligand-Target Pair
TargetEukaryotic elongation factor 2 kinase(Homo sapiens (Human))TBA
LigandPNGBDBM166686(2-methyl-5-(propan-2-yl)cyclohexa-2,5-diene-1,4-di...)
Affinity DataIC50:  8.20E+3nMAssay Description:Antagonist potency against histamine H3 receptor in an electrically stimulated guinea pig ileumMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetSerine/threonine-protein kinase PLK3(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM166686(2-methyl-5-(propan-2-yl)cyclohexa-2,5-diene-1,4-di...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of recombinant Plk3 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase PLK2(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM166686(2-methyl-5-(propan-2-yl)cyclohexa-2,5-diene-1,4-di...)
Affinity DataIC50:  1.47E+4nMAssay Description:Inhibition of recombinant Plk2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed