BDBM172110 US10155002, Compound 116::US11052093, Compound 116::US9090562, 116

SMILES Cc1cc(C)c(CNC(=O)c2cc(cc(NC3CCOCC3)c2C)-c2ccc(CN3CCOCC3)cc2)c(=O)[nH]1

InChI Key InChIKey=HKMWGEDYIRAFJN-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 172110   

LigandChemical structure of BindingDB Monomer ID 172110BDBM172110(US9090562, 116 | US10155002, Compound 116 | US1105...)
Affinity DataIC50: 1.23E+3nMT: 2°CAssay Description:The assays were all performed in a buffer consisting of 20 mM bicine (pH=7.6), 0.5 mM DTT, 0.005% BSG and 0.002% Tween20, prepared on the day of use....More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2016
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 172110BDBM172110(US9090562, 116 | US10155002, Compound 116 | US1105...)
Affinity DataIC50: 1.23E+3nMAssay Description:The assays were all performed in a buffer consisting of 20 mM bicine (pH=7.6), 0.5 mM DTT, 0.005% BSG and 0.002% Tween20, prepared on the day of use....More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2019
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 172110BDBM172110(US9090562, 116 | US10155002, Compound 116 | US1105...)
Affinity DataIC50: 1.23E+3nMAssay Description:The assays were all performed in a buffer consisting of 20 mM bicine (pH=7.6), 0.5 mM DTT, 0.005% BSG and 0.002% Tween20, prepared on the day of use....More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2022
Entry Details
US Patent

TargetHistone-lysine N-methyltransferase EZH2(Human)
Epizyme

US Patent
LigandChemical structure of BindingDB Monomer ID 172110BDBM172110(US9090562, 116 | US10155002, Compound 116 | US1105...)
Affinity DataIC50: 1.79E+3nMT: 2°CAssay Description:The assays were all performed in a buffer consisting of 20 mM bicine (pH=7.6), 0.5 mM DTT, 0.005% BSG and 0.002% Tween20, prepared on the day of use....More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2016
Entry Details
US Patent

TargetHistone-lysine N-methyltransferase EZH2(Human)
Epizyme

US Patent
LigandChemical structure of BindingDB Monomer ID 172110BDBM172110(US9090562, 116 | US10155002, Compound 116 | US1105...)
Affinity DataIC50: 1.79E+3nMAssay Description:The assays were all performed in a buffer consisting of 20 mM bicine (pH=7.6), 0.5 mM DTT, 0.005% BSG and 0.002% Tween20, prepared on the day of use....More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2019
Entry Details
US Patent

TargetHistone-lysine N-methyltransferase EZH2(Human)
Epizyme

US Patent
LigandChemical structure of BindingDB Monomer ID 172110BDBM172110(US9090562, 116 | US10155002, Compound 116 | US1105...)
Affinity DataIC50: 1.79E+3nMAssay Description:The assays were all performed in a buffer consisting of 20 mM bicine (pH=7.6), 0.5 mM DTT, 0.005% BSG and 0.002% Tween20, prepared on the day of use....More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2022
Entry Details
US Patent