BDBM209865 2-N-[2-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl]-4-N-(2-propan-2-ylsulfonylphenyl)-1,3,5-triazine-2,4-diamine::ASP-3026

SMILES CC(C)S(=O)(=O)c1ccccc1Nc2ncnc(n2)Nc3ccc(cc3OC)N4CCC(CC4)N5CCN(CC5)C

InChI Key InChIKey=MGGBYMDAPCCKCT-UHFFFAOYSA-N

Data  1 Kd

PDB links: 1 PDB ID matches this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 30 hits for monomerid = 209865   

TargetALK tyrosine kinase receptor(Human)
Astellas Pharma Inc.

Curated by ChEMBL
LigandPNGBDBM209865(ASP-3026 | 2-N-[2-methoxy-4-[4-(4-methylpiperazin-...)
Affinity DataIC50: 3.5nMAssay Description:Inhibition of human N-terminal GST-fused ALK cytoplasmic domain (1058 to 1620(end) residues) expressed in baculovirus expression system using Srctide...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetALK tyrosine kinase receptor(Human)
Astellas Pharma Inc.

Curated by ChEMBL
LigandPNGBDBM209865(ASP-3026 | 2-N-[2-methoxy-4-[4-(4-methylpiperazin-...)
Affinity DataIC50: 5.40nMAssay Description:Inhibition of human N-terminal GST-fused ALK R1275Q mutant cytoplasmic domain (1058 to 1620(end) residues) expressed in baculovirus expression system...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetActivated CDC42 kinase 1(Human)
Astellas Pharma Inc.

Curated by ChEMBL
LigandPNGBDBM209865(ASP-3026 | 2-N-[2-methoxy-4-[4-(4-methylpiperazin-...)
Affinity DataIC50: 5.80nMAssay Description:Inhibition of human N-terminal GST-fused ACK catalytic domain (110 to 476 residues) expressed in baculovirus expression system using WASP peptide as ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Astellas Pharma Inc.

Curated by ChEMBL
LigandPNGBDBM209865(ASP-3026 | 2-N-[2-methoxy-4-[4-(4-methylpiperazin-...)
Affinity DataIC50: 6.80nMAssay Description:Inhibition of human N-terminal GST-fused NPM1-ALK (1 to 680 residues) expressed in baculovirus expression system using Srctide as substrate measured ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetProto-oncogene tyrosine-protein kinase ROS(Human)
Astellas Pharma Inc.

Curated by ChEMBL
LigandPNGBDBM209865(ASP-3026 | 2-N-[2-methoxy-4-[4-(4-methylpiperazin-...)
Affinity DataIC50: 8.90nMAssay Description:Inhibition of human N-terminal GST-fused ROS cytoplasmic domain (1883 to 2347(end) residues) expressed in baculovirus expression system using IRS1 as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetALK tyrosine kinase receptor(Human)
Astellas Pharma Inc.

Curated by ChEMBL
LigandPNGBDBM209865(ASP-3026 | 2-N-[2-methoxy-4-[4-(4-methylpiperazin-...)
Affinity DataIC50: 10nMAssay Description:Inhibition of human N-terminal GST-fused ALK F1174L mutant cytoplasmic domain (1058 to 1620(end) residues) expressed in baculovirus expression system...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Astellas Pharma Inc.

Curated by ChEMBL
LigandPNGBDBM209865(ASP-3026 | 2-N-[2-methoxy-4-[4-(4-methylpiperazin-...)
Affinity DataIC50: 10nMAssay Description:Inhibition of EML4-ALK (unknown origin) transformed in mouse BaF3 cells by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetNon-receptor tyrosine-protein kinase TNK1(Human)
Astellas Pharma Inc.

Curated by ChEMBL
LigandPNGBDBM209865(ASP-3026 | 2-N-[2-methoxy-4-[4-(4-methylpiperazin-...)
Affinity DataIC50: 27nMAssay Description:Inhibition of human N-terminal GST-fused TNK1 isoform 2 catalytic domain (106 to 390 residues) expressed in baculovirus expression system using CSKti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetTyrosine-protein kinase Yes(Human)
Astellas Pharma Inc.

Curated by ChEMBL
LigandPNGBDBM209865(ASP-3026 | 2-N-[2-methoxy-4-[4-(4-methylpiperazin-...)
Affinity DataIC50: 32nMAssay Description:Inhibition of human full-length N-terminal GST-fused YES (1 to 543(end) residues) expressed in baculovirus expression system using Srctide as substra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Astellas Pharma Inc.

Curated by ChEMBL
LigandPNGBDBM209865(ASP-3026 | 2-N-[2-methoxy-4-[4-(4-methylpiperazin-...)
Affinity DataIC50: 32nMAssay Description:Inhibition of EML4-ALK L1196M mutant (unknown origin) transformed in mouse BaF3 cells by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetTyrosine-protein kinase FRK(Human)
Astellas Pharma Inc.

Curated by ChEMBL
LigandPNGBDBM209865(ASP-3026 | 2-N-[2-methoxy-4-[4-(4-methylpiperazin-...)
Affinity DataIC50: 40nMAssay Description:Inhibition of human N-terminal GST-fused FRK catalytic domain (223 to 505(end) residues) expressed in baculovirus expression system using Srctide as ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Astellas Pharma Inc.

Curated by ChEMBL
LigandPNGBDBM209865(ASP-3026 | 2-N-[2-methoxy-4-[4-(4-methylpiperazin-...)
Affinity DataIC50: 42nMAssay Description:Inhibition of EML4-ALK (unknown origin) expressed in mouse 3T3 cells assessed as growth inhibition measured after 2 days by celltiter-glo luminescent...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetLeukocyte tyrosine kinase receptor(Human)
Astellas Pharma Inc.

Curated by ChEMBL
LigandPNGBDBM209865(ASP-3026 | 2-N-[2-methoxy-4-[4-(4-methylpiperazin-...)
Affinity DataIC50: 61nMAssay Description:Inhibition of human N-terminal GST-fused LTK catalytic domain (498 to 796 residues) expressed in baculovirus expression system using Srctide as subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Astellas Pharma Inc.

Curated by ChEMBL
LigandPNGBDBM209865(ASP-3026 | 2-N-[2-methoxy-4-[4-(4-methylpiperazin-...)
Affinity DataIC50: 86nMAssay Description:Inhibition of human N-terminal GST-fused EGFR L858R mutant cytoplasmic domain (669 to 1210(end) residues) expressed in baculovirus expression system ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetMuscle, skeletal receptor tyrosine-protein kinase(Human)
Astellas Pharma Inc.

Curated by ChEMBL
LigandPNGBDBM209865(ASP-3026 | 2-N-[2-methoxy-4-[4-(4-methylpiperazin-...)
Affinity DataIC50: 100nMAssay Description:Inhibition of human N-terminal GST-fused MUSK catalytic domain (527 to 869(end) residues) expressed in baculovirus expression system using CSKtide as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetTyrosine-protein kinase receptor UFO(Human)
Astellas Pharma Inc.

Curated by ChEMBL
LigandPNGBDBM209865(ASP-3026 | 2-N-[2-methoxy-4-[4-(4-methylpiperazin-...)
Affinity DataIC50: 100nMAssay Description:Inhibition of human N-terminal GST-fused AXL cytoplasmic domain (464 to 885(end) residues) expressed in baculovirus expression system using CSKtide a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetTyrosine-protein kinase Lck(Human)
Astellas Pharma Inc.

Curated by ChEMBL
LigandPNGBDBM209865(ASP-3026 | 2-N-[2-methoxy-4-[4-(4-methylpiperazin-...)
Affinity DataIC50: 100nMAssay Description:Inhibition of human full-length N-terminal GST-fused LCK (1 to 509(end) residues) expressed in baculovirus expression system using Srctide as substra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Astellas Pharma Inc.

Curated by ChEMBL
LigandPNGBDBM209865(ASP-3026 | 2-N-[2-methoxy-4-[4-(4-methylpiperazin-...)
Affinity DataIC50: 163nMAssay Description:Inhibition of EML4-ALK L1196M mutant (unknown origin) expressed in mouse 3T3 cells assessed as growth inhibition measured after 2 days by celltiter-g...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetEphrin type-A receptor 2 [596-900](Human)
Technical University of Munich

LigandPNGBDBM209865(ASP-3026 | 2-N-[2-methoxy-4-[4-(4-methylpiperazin-...)
Affinity DataKd:  640nMAssay Description:Kinobeads competition assays were performed in 96-well format as previously described using mixed protein lysates of four cancer cell lines (K-562, M...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2017
Entry Details Article
PubMed
TargetMacrophage-stimulating protein receptor(Human)
Astellas Pharma Inc.

Curated by ChEMBL
LigandPNGBDBM209865(ASP-3026 | 2-N-[2-methoxy-4-[4-(4-methylpiperazin-...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human N-terminal GST-fused RON cytoplasmic domain (979 to 1400(end) residues) expressed in baculovirus expression system using Srctide ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetEphrin type-B receptor 4(Human)
Astellas Pharma Inc.

Curated by ChEMBL
LigandPNGBDBM209865(ASP-3026 | 2-N-[2-methoxy-4-[4-(4-methylpiperazin-...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human N-terminal GST-fused EPHB4 cytoplasmic domain (577 to 987(end) residues) expressed in baculovirus expression system using Blk/Lyn...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetEphrin type-A receptor 6(Human)
Astellas Pharma Inc.

Curated by ChEMBL
LigandPNGBDBM209865(ASP-3026 | 2-N-[2-methoxy-4-[4-(4-methylpiperazin-...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human N-terminal GST-fused EPHA6 cytoplasmic domain (683 to 1130(end) residues) expressed in baculovirus expression system using Blk/Ly...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Astellas Pharma Inc.

Curated by ChEMBL
LigandPNGBDBM209865(ASP-3026 | 2-N-[2-methoxy-4-[4-(4-methylpiperazin-...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human N-terminal His-tagged JAK2 catalytic domain (826 to 1132(end) residues) expressed in baculovirus expression system using Srctide ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetBDNF/NT-3 growth factors receptor(Human)
Astellas Pharma Inc.

Curated by ChEMBL
LigandPNGBDBM209865(ASP-3026 | 2-N-[2-methoxy-4-[4-(4-methylpiperazin-...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human N-terminal GST-fused TRKB cytoplasmic domain (456 to 822(end) residues) expressed in baculovirus expression system using Srctide ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetHigh affinity nerve growth factor receptor(Human)
Astellas Pharma Inc.

Curated by ChEMBL
LigandPNGBDBM209865(ASP-3026 | 2-N-[2-methoxy-4-[4-(4-methylpiperazin-...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human N-terminal GST-fused TRKA cytoplasmic domain (436 to 790(end) residues) expressed in baculovirus expression system using CSKtide ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetEphrin type-A receptor 2(Human)
Astellas Pharma Inc.

Curated by ChEMBL
LigandPNGBDBM209865(ASP-3026 | 2-N-[2-methoxy-4-[4-(4-methylpiperazin-...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human N-terminal GST-fused EPHA2 cytoplasmic domain (572 to 976(end) residues) expressed in baculovirus expression system using Blk/Lyn...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetTyrosine-protein kinase receptor TYRO3(Human)
Astellas Pharma Inc.

Curated by ChEMBL
LigandPNGBDBM209865(ASP-3026 | 2-N-[2-methoxy-4-[4-(4-methylpiperazin-...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human N-terminal GST-fused TYRO3 cytoplasmic domain (453 to 890(end) residues) expressed in baculovirus expression system using CSKtide...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetHepatocyte growth factor receptor(Human)
Astellas Pharma Inc.

Curated by ChEMBL
LigandPNGBDBM209865(ASP-3026 | 2-N-[2-methoxy-4-[4-(4-methylpiperazin-...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human N-terminal GST-fused MET cytoplasmic domain ([956 to 1390(end) residues) expressed in baculovirus expression system using Srctide...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetNT-3 growth factor receptor(Human)
Astellas Pharma Inc.

Curated by ChEMBL
LigandPNGBDBM209865(ASP-3026 | 2-N-[2-methoxy-4-[4-(4-methylpiperazin-...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human N-terminal GST-fused TRKC cytoplasmic domain (456 to 825(end) residues) expressed in baculovirus expression system using Srctide ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetTyrosine-protein kinase Mer(Human)
Astellas Pharma Inc.

Curated by ChEMBL
LigandPNGBDBM209865(ASP-3026 | 2-N-[2-methoxy-4-[4-(4-methylpiperazin-...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human N-terminal GST-fused MER cytoplasmic domain (528 to 999(end) residues) expressed in baculovirus expression system using CSKtide a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed