BDBM212969 US9278960, 4-53::US9663506, Example 4-53

SMILES Cn1cc(cn1)-c1cc(nc2cc(CN3CCO[C@@H](C3)C(F)(F)F)ccc12)C(N)=O

InChI Key InChIKey=PUIAIYDBFPDZPF-SFHVURJKSA-N

Data  3 IC50

PDB links: 2 PDB IDs match this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 212969   

LigandPNGBDBM212969(US9278960, 4-53 | US9663506, Example 4-53)
Affinity DataIC50:  25nMAssay Description:The utility of the compounds in accordance with the present invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM212969(US9278960, 4-53 | US9663506, Example 4-53)
Affinity DataIC50:  25nMAssay Description:The utility of the compounds in accordance with the present invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM212969(US9278960, 4-53 | US9663506, Example 4-53)
Affinity DataIC50:  25nMAssay Description:The utility of the compounds in accordance with the present invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB