BDBM217379 CDDO-Me, 2

SMILES C[C@@]12CC[C@]3(CCC(C[C@H]3[C@H]1C(=O)C=C4[C@]2(CC[C@@H]5[C@@]4(C=C(C(=O)C5(C)C)C#N)C)C)(C)C)C(=O)OC

InChI Key InChIKey=WPTTVJLTNAWYAO-UHFFFAOYSA-N

Data  5 IC50  1 EC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 217379   

TargetNuclear factor erythroid 2-related factor 2(Human)
University of Eastern Piedmont

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 217379BDBM217379(CDDO-Me, 2)
Affinity DataEC50:  60nMAssay Description:Activation of Nrf2 (unknown origin) expressed in human HaCaT-ARE-luc cells after 6 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetSignal transducer and activator of transcription 3(Human)
University of Eastern Piedmont

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 217379BDBM217379(CDDO-Me, 2)
Affinity DataIC50: 2.38E+3nMAssay Description:Inhibition of IFN-gamma stimulated STAT3 (unknown origin) expressed in human HeLa cells after 6 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Baylor College of Medicine

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 217379BDBM217379(CDDO-Me, 2)
Affinity DataIC50: 5.81E+3nMAssay Description:Inhibition of SARS-CoV-2 MPro using Dabcyl-KTSAVLQSGFRKME-Edans as substrate preincubated for 30 mins followed by substrate addition measured after 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetGhrelin O-acyltransferase(Human)
Syracuse University

LigandChemical structure of BindingDB Monomer ID 217379BDBM217379(CDDO-Me, 2)
Affinity DataIC50: 6.00E+3nMpH: 7.0 T: 2°CAssay Description:Assays were performed with ~100 μg of membrane protein, as determined by a Bradford assay. The membrane fraction was preincubated with 1 μM met...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/17/2017
Entry Details Article
PubMed
TargetGhrelin O-acyltransferase(Human)
Syracuse University

LigandChemical structure of BindingDB Monomer ID 217379BDBM217379(CDDO-Me, 2)
Affinity DataIC50: 6.00E+3nMAssay Description:Inhibition of N-terminal His-tagged human GOAT expressed in Sf9 cells incubated for 1 hr by Bradford assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetUbiquitin carboxyl-terminal hydrolase 7(Human)
Progenra

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 217379BDBM217379(CDDO-Me, 2)
Affinity DataIC50: 1.41E+4nMAssay Description:Inhibition of USP7 (unknown origin) using human N-terminal GST-tagged UBA52 as substrate preincubated for 10 mins followed by substrate addition meas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2020
Entry Details Article
PubMed
TargetUbiquitin carboxyl-terminal hydrolase 2(Human)
Progenra

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 217379BDBM217379(CDDO-Me, 2)
Affinity DataIC50: 2.20E+4nMAssay Description:Inhibition of USP2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2020
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Crystal Pharmatech

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 217379BDBM217379(CDDO-Me, 2)
Affinity DataIC50: 2.00E+5nMAssay Description:Inhibition of human ERG expressed in CHO cells at -80 mV holding potential by patch clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/14/2019
Entry Details Article
PubMed