BDBM22369 4-(4-methanesulfonylphenyl)-3-phenyl-2,5-dihydrofuran-2-one::CHEMBL122::MK 0966::Rofecoxib::US11478464, Compound Rofecoxib::US11786535, Compound Rofecoxib

SMILES CS(=O)(=O)c1ccc(cc1)C2=C(C(=O)OC2)c3ccccc3

InChI Key InChIKey=RZJQGNCSTQAWON-UHFFFAOYSA-N

Data  26 KI  170 IC50

PDB links: 1 PDB ID matches this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 196 hits for monomerid = 22369   

TargetProstaglandin G/H synthase 2(Human)
Laboratoires Innothera

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 22369BDBM22369(CHEMBL122 | MK 0966 | 4-(4-methanesulfonylphenyl)-...)
Affinity DataIC50: 1nMAssay Description:The compound was evaluated for prostaglandin E2 inhibition using recombinant Prostaglandin G/H synthase 2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetProstaglandin G/H synthase 2(Mouse)
Sapienza University of Rome

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 22369BDBM22369(CHEMBL122 | MK 0966 | 4-(4-methanesulfonylphenyl)-...)
Affinity DataIC50: 12nMAssay Description:In vitro inhibitory activity against Prostaglandin G/H synthase 2 in murine J774 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetProstaglandin G/H synthase 2(Human)
Laboratoires Innothera

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 22369BDBM22369(CHEMBL122 | MK 0966 | 4-(4-methanesulfonylphenyl)-...)
Affinity DataIC50: 12nMAssay Description:In vitro inhibitory activity against human Prostaglandin G/H synthase 2 (COX-2) in 143982 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetProstaglandin G/H synthase 2(Human)
Laboratoires Innothera

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 22369BDBM22369(CHEMBL122 | MK 0966 | 4-(4-methanesulfonylphenyl)-...)
Affinity DataIC50: 15nMAssay Description:Inhibitory concentration against COX-2 upon incubation for 15 minutes at 37 degree CMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetProstaglandin G/H synthase 2(Human)
Laboratoires Innothera

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 22369BDBM22369(CHEMBL122 | MK 0966 | 4-(4-methanesulfonylphenyl)-...)
Affinity DataIC50: 18nMAssay Description:Inhibition of COX2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetProstaglandin E2 receptor EP2 subtype(Human)
Merck Frosst Centre For Therapeutic Research

Curated by PDSP Ki Database
LigandChemical structure of BindingDB Monomer ID 22369BDBM22369(CHEMBL122 | MK 0966 | 4-(4-methanesulfonylphenyl)-...)
Affinity DataKi:  18nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/12/2012
Entry Details
PubMed
TargetProstaglandin G/H synthase 2(Human)
Laboratoires Innothera

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 22369BDBM22369(CHEMBL122 | MK 0966 | 4-(4-methanesulfonylphenyl)-...)
Affinity DataIC50: 20nMAssay Description:In vitro inhibitory activity against human whole cells (CHO) Prostaglandin G/H synthase 2More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/29/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetProstaglandin G/H synthase 2(Human)
Laboratoires Innothera

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 22369BDBM22369(CHEMBL122 | MK 0966 | 4-(4-methanesulfonylphenyl)-...)
Affinity DataIC50: 20nMAssay Description:In vitro inhibitory potency against human COX-2 in stably transfected chinese hamster ovary (CHO) cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetProstaglandin G/H synthase 2(Human)
Laboratoires Innothera

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 22369BDBM22369(CHEMBL122 | MK 0966 | 4-(4-methanesulfonylphenyl)-...)
Affinity DataIC50: 20nMAssay Description:Inhibition of PGE-2 production in CHO cells expressing human COX-2.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetProstaglandin G/H synthase 2(Human)
Laboratoires Innothera

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 22369BDBM22369(CHEMBL122 | MK 0966 | 4-(4-methanesulfonylphenyl)-...)
Affinity DataIC50: 20nMAssay Description:Inhibitory of human Prostaglandin G/H synthase 2 expressed in CHO cells.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetProstaglandin G/H synthase 2(Human)
Laboratoires Innothera

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 22369BDBM22369(CHEMBL122 | MK 0966 | 4-(4-methanesulfonylphenyl)-...)
Affinity DataIC50: 20nMAssay Description:In vitro potency against human Prostaglandin G/H synthase 2 in transfected CHO cells.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/14/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCytochrome c oxidase subunit 2(Human)
National Institute of Pharmaceutical Education and Research (NIPER)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 22369BDBM22369(CHEMBL122 | MK 0966 | 4-(4-methanesulfonylphenyl)-...)
Affinity DataIC50: 20nMAssay Description:Inhibition of COX2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
King Faisal University

US Patent
LigandChemical structure of BindingDB Monomer ID 22369BDBM22369(CHEMBL122 | MK 0966 | 4-(4-methanesulfonylphenyl)-...)
Affinity DataIC50: 25nMAssay Description:The inhibitory effects of candidate compounds on COX-1 and COX-2 were determined using COX inhibitor screening test kits, testing each compound's...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2023
Entry Details
US Patent
PDB3D3D Structure (crystal)
TargetProstaglandin G/H synthase 2(Human)
Laboratoires Innothera

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 22369BDBM22369(CHEMBL122 | MK 0966 | 4-(4-methanesulfonylphenyl)-...)
Affinity DataIC50: 25nMAssay Description:Inhibitory concentration against COX-2; (valus obtained by Kato et al.)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetProstaglandin G/H synthase 2(Human)
King Faisal University

US Patent
LigandChemical structure of BindingDB Monomer ID 22369BDBM22369(CHEMBL122 | MK 0966 | 4-(4-methanesulfonylphenyl)-...)
Affinity DataIC50: 25nMAssay Description:The inhibitory effects of candidate compounds on COX-1 and COX-2 were determined using COX inhibitor screening test kits, testing each compound's...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2022
Entry Details
US Patent
PDB3D3D Structure (crystal)
TargetProstaglandin E2 receptor EP2 subtype(Human)
Merck Frosst Centre For Therapeutic Research

Curated by PDSP Ki Database
LigandChemical structure of BindingDB Monomer ID 22369BDBM22369(CHEMBL122 | MK 0966 | 4-(4-methanesulfonylphenyl)-...)
Affinity DataKi:  26nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/12/2012
Entry Details
PubMed
TargetProstaglandin G/H synthase 2(Human)
Laboratoires Innothera

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 22369BDBM22369(CHEMBL122 | MK 0966 | 4-(4-methanesulfonylphenyl)-...)
Affinity DataIC50: 27nMAssay Description:Inhibition of COX-2 (unknown origin) using arachidonic acid as substrate preincubated for 10 mins followed by substrate addition measured after 2 min...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetProstaglandin G/H synthase 2(Human)
Laboratoires Innothera

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 22369BDBM22369(CHEMBL122 | MK 0966 | 4-(4-methanesulfonylphenyl)-...)
Affinity DataIC50: 32nMAssay Description:Inhibition of human cyclooxygenase-2 expressed in COS cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetProstaglandin G/H synthase 2(Human)
Laboratoires Innothera

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 22369BDBM22369(CHEMBL122 | MK 0966 | 4-(4-methanesulfonylphenyl)-...)
Affinity DataIC50: 32nMAssay Description:Inhibition of human COX2 expressed in african green monkey COS cells assessed as inhibition of arachidonic acid-stimulated PGE2 production treated 1 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetProstaglandin E2 receptor EP3 subtype(Rat)
Merck Frosst Centre For Therapeutic Research

Curated by PDSP Ki Database
LigandChemical structure of BindingDB Monomer ID 22369BDBM22369(CHEMBL122 | MK 0966 | 4-(4-methanesulfonylphenyl)-...)
Affinity DataKi:  41nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/12/2012
Entry Details
PubMed
TargetProstaglandin E2 receptor EP2 subtype(Human)
Merck Frosst Centre For Therapeutic Research

Curated by PDSP Ki Database
LigandChemical structure of BindingDB Monomer ID 22369BDBM22369(CHEMBL122 | MK 0966 | 4-(4-methanesulfonylphenyl)-...)
Affinity DataKi:  45nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/12/2012
Entry Details
PubMed
TargetProstaglandin E2 receptor EP3 subtype(Rat)
Merck Frosst Centre For Therapeutic Research

Curated by PDSP Ki Database
LigandChemical structure of BindingDB Monomer ID 22369BDBM22369(CHEMBL122 | MK 0966 | 4-(4-methanesulfonylphenyl)-...)
Affinity DataKi:  46nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/12/2012
Entry Details
PubMed
TargetProstaglandin G/H synthase 2(Human)
Laboratoires Innothera

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 22369BDBM22369(CHEMBL122 | MK 0966 | 4-(4-methanesulfonylphenyl)-...)
Affinity DataIC50: 57nMAssay Description:Inhibitory activity against Prostaglandin G/H synthase 2 in human whole blood assay as LPS induced PGE-2 generation.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetProstaglandin G/H synthase 2(Mouse)
Sapienza University of Rome

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 22369BDBM22369(CHEMBL122 | MK 0966 | 4-(4-methanesulfonylphenyl)-...)
Affinity DataIC50: 60nMAssay Description:Inhibition of mouse COX-2 assessed as inhibition of [14C]arachidonic acid to radiolabeled prostaglandins preincubated for 15 mins by TLC-based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetProstaglandin G/H synthase 2(Human)
Laboratoires Innothera

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 22369BDBM22369(CHEMBL122 | MK 0966 | 4-(4-methanesulfonylphenyl)-...)
Affinity DataIC50: 75nMAssay Description:Inhibition of human recombinant COX2 expressed in Sf21 cells assessed as effect on prostaglandin E2 production by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetProstaglandin G/H synthase 2(Human)
Laboratoires Innothera

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 22369BDBM22369(CHEMBL122 | MK 0966 | 4-(4-methanesulfonylphenyl)-...)
Affinity DataIC50: 107nMAssay Description:Inhibition of human COX2 expressed in baculovirus-infected SF9 cells assessed as inhibition of arachidonic acid-stimulated PGE2 production treated 1 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetProstaglandin G/H synthase 2(Human)
Laboratoires Innothera

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 22369BDBM22369(CHEMBL122 | MK 0966 | 4-(4-methanesulfonylphenyl)-...)
Affinity DataIC50: 120nMAssay Description:Inhibition of human recombinant COX2 expressed in insect Sf21 cells by EIA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetProstaglandin G/H synthase 2(Human)
Laboratoires Innothera

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 22369BDBM22369(CHEMBL122 | MK 0966 | 4-(4-methanesulfonylphenyl)-...)
Affinity DataIC50: 156nMAssay Description:Inhibition of human recombinant COX2 expressed in Sf21 cells assessed as PGE2 production using arachidonic acid as substrate preincubated for 15 mins...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetProstaglandin G/H synthase 2(Human)
Laboratoires Innothera

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 22369BDBM22369(CHEMBL122 | MK 0966 | 4-(4-methanesulfonylphenyl)-...)
Affinity DataIC50: 170nMAssay Description:Inhibition of human recombinant COX2 expressed in Sf21 cells assessed as conversion of arachidonic acid to PGE2 preincubated for 15 mins measured aft...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetProstaglandin G/H synthase 2(Human)
Laboratoires Innothera

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 22369BDBM22369(CHEMBL122 | MK 0966 | 4-(4-methanesulfonylphenyl)-...)
Affinity DataIC50: 170nMAssay Description:Inhibition of human recombinant COX2 expressed in Sf21 cells using arachidonic acid as substrate preincubated for 15 mins before arachidonic acid add...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetProstaglandin G/H synthase 2(Mouse)
Sapienza University of Rome

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 22369BDBM22369(CHEMBL122 | MK 0966 | 4-(4-methanesulfonylphenyl)-...)
Affinity DataIC50: 190nMAssay Description:In vitro inhibitory activity against prostaglandin G/H synthase 2 using mouse peritoneal macrophage methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetProstaglandin G/H synthase 2(Mouse)
Sapienza University of Rome

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 22369BDBM22369(CHEMBL122 | MK 0966 | 4-(4-methanesulfonylphenyl)-...)
Affinity DataIC50: 190nMAssay Description:Ability to inhibit Prostaglandin G/H synthase 2 by using freshly harvested mouse peritoneal macrophagesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2018
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetProstaglandin G/H synthase 2(Human)
Laboratoires Innothera

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 22369BDBM22369(CHEMBL122 | MK 0966 | 4-(4-methanesulfonylphenyl)-...)
Affinity DataIC50: 196nMAssay Description:Inhibitory concentration against Prostaglandin G/H synthase 2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetProstaglandin G/H synthase 2(Human)
Laboratoires Innothera

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 22369BDBM22369(CHEMBL122 | MK 0966 | 4-(4-methanesulfonylphenyl)-...)
Affinity DataIC50: 210nMAssay Description:Inhibition of PGE-2 generation in LPS-stimulated human monocytes (Prostaglandin G/H synthase 2 cell assay)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetProstaglandin G/H synthase 2(Human)
Laboratoires Innothera

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 22369BDBM22369(CHEMBL122 | MK 0966 | 4-(4-methanesulfonylphenyl)-...)
Affinity DataIC50: 211nMAssay Description:Inhibition of human COX2 in human whole bloodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetProstaglandin G/H synthase 2(Human)
Laboratoires Innothera

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 22369BDBM22369(CHEMBL122 | MK 0966 | 4-(4-methanesulfonylphenyl)-...)
Affinity DataIC50: 260nMAssay Description:Inhibition of COX2 in human whole blood assessed as inhibition of lipopolysaccharide-stimulated PGE2 production after 24 hrs by enzyme immunoassayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetProstaglandin G/H synthase 2(Human)
Laboratoires Innothera

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 22369BDBM22369(CHEMBL122 | MK 0966 | 4-(4-methanesulfonylphenyl)-...)
Affinity DataIC50: 280nMAssay Description:In vitro inhibition of PGE-2 generation by LPS-stimulated monocytes isolated from human blood.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetProstaglandin G/H synthase 2(Human)
Laboratoires Innothera

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 22369BDBM22369(CHEMBL122 | MK 0966 | 4-(4-methanesulfonylphenyl)-...)
Affinity DataIC50: 280nMAssay Description:In vitro percent inhibition of Prostaglandin G/H synthase 2 (COX-2) in human whole blood was determinedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetProstaglandin G/H synthase 2(Human)
Laboratoires Innothera

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 22369BDBM22369(CHEMBL122 | MK 0966 | 4-(4-methanesulfonylphenyl)-...)
Affinity DataIC50: 292nMAssay Description:Inhibition of human COX2More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetProstaglandin G/H synthase 2(Sheep)
Guru Nanak Dev University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 22369BDBM22369(CHEMBL122 | MK 0966 | 4-(4-methanesulfonylphenyl)-...)
Affinity DataIC50: 300nMAssay Description:Inhibition of ovine COX2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetProstaglandin G/H synthase 2(Human)
Laboratoires Innothera

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 22369BDBM22369(CHEMBL122 | MK 0966 | 4-(4-methanesulfonylphenyl)-...)
Affinity DataIC50: 300nMAssay Description:Compound was tested for the inhibition of human Prostaglandin G/H synthase 2 (COX-2) in human whole bloodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetProstaglandin G/H synthase 2(Human)
Laboratoires Innothera

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 22369BDBM22369(CHEMBL122 | MK 0966 | 4-(4-methanesulfonylphenyl)-...)
Affinity DataIC50: 300nMAssay Description:Compound was evaluated for inhibition concentration of prostaglandin G/H synthase 2 in human bloodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetProstaglandin G/H synthase 2(Human)
Laboratoires Innothera

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 22369BDBM22369(CHEMBL122 | MK 0966 | 4-(4-methanesulfonylphenyl)-...)
Affinity DataIC50: 300nMAssay Description:Inhibition of COX2More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetProstaglandin G/H synthase 2(Human)
Laboratoires Innothera

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 22369BDBM22369(CHEMBL122 | MK 0966 | 4-(4-methanesulfonylphenyl)-...)
Affinity DataIC50: 300nMAssay Description:In vitro inhibition of Prostaglandin G/H synthase 2 in human whole bloodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetProstaglandin G/H synthase 2(Human)
Laboratoires Innothera

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 22369BDBM22369(CHEMBL122 | MK 0966 | 4-(4-methanesulfonylphenyl)-...)
Affinity DataKi:  310nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/12/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetProstaglandin G/H synthase 2(Human)
Laboratoires Innothera

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 22369BDBM22369(CHEMBL122 | MK 0966 | 4-(4-methanesulfonylphenyl)-...)
Affinity DataIC50: 329nMAssay Description:In vitro inhibitory activity against recombinant human Prostaglandin G/H synthase 2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetProstaglandin G/H synthase 2(Human)
Laboratoires Innothera

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 22369BDBM22369(CHEMBL122 | MK 0966 | 4-(4-methanesulfonylphenyl)-...)
Affinity DataKi:  340nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/12/2012
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetProstaglandin G/H synthase 2(Human)
Laboratoires Innothera

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 22369BDBM22369(CHEMBL122 | MK 0966 | 4-(4-methanesulfonylphenyl)-...)
Affinity DataIC50: 340nMAssay Description:Inhibition of COX2More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetProstaglandin G/H synthase 2(Human)
Laboratoires Innothera

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 22369BDBM22369(CHEMBL122 | MK 0966 | 4-(4-methanesulfonylphenyl)-...)
Affinity DataIC50: 340nMAssay Description:Inhibitory concentration against Prostaglandin G/H synthase 2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetProstaglandin G/H synthase 2(Human)
Laboratoires Innothera

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 22369BDBM22369(CHEMBL122 | MK 0966 | 4-(4-methanesulfonylphenyl)-...)
Affinity DataIC50: 340nMAssay Description:Inhibition of human Prostaglandin G/H synthase 2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
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