BDBM226354 US9328096, 47

SMILES CC(C)(O)CNC(=O)c1cc(NC(=O)c2cc(c(Cl)cc2Cl)-c2ccccn2)n(n1)-c1ccccc1

InChI Key InChIKey=NXDRKVFQQJUBOG-UHFFFAOYSA-N

Data  9 IC50  1 Kd

PDB links: 1 PDB ID matches this monomer.

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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 226354   

TargetHigh affinity nerve growth factor receptor [441-796](Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM226354(US9328096, 47)
Affinity DataIC50:  12.4nMT: 2°CAssay Description:TRKA co-expressed with p75: The assays are based upon DiscoveRx's proprietary Enzyme Fragment Complementation (EFC) technology. In the case of the TR...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetHigh affinity nerve growth factor receptor(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM226354(US9328096, 47)
Affinity DataIC50:  6nMAssay Description:Antagonist activity at unphosphorylated rat TrkA expressed in baculovirus expression system preincubated for 20 mins followed by TK-substrate-Biotin ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetHigh affinity nerve growth factor receptor(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM226354(US9328096, 47)
Affinity DataIC50:  57nMAssay Description:Antagonist activity at TrkA in rat DRG assessed as inhibition of NGF-induced ERK phosphorylation preincubated for 60 mins followed by NGF addition an...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM226354(US9328096, 47)
Affinity DataKd:  4.20nMAssay Description:Binding affinity to C-terminal-His6/N-terminal BAP-tagged unphosphorylated TrkA (unknown origin) (441 to 796 residues) by SPR analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetNT-3 growth factor receptor(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM226354(US9328096, 47)
Affinity DataIC50:  700nMAssay Description:Inhibition of TRKC (unknown origin) in presence of [gamma33P]ATP by radiometric HotSpot assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails PubMed
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM226354(US9328096, 47)
Affinity DataIC50:  74nMAssay Description:Antagonist activity at phosphorylated human His-tagged TrkA (441 to 796 residues) expressed in baculovirus expression system preincubated for 20 mins...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM226354(US9328096, 47)
Affinity DataIC50:  4nMAssay Description:Antagonist activity at unphosphorylated human His-tagged TrkA (441 to 796 residues) expressed in baculovirus expression system preincubated for 20 mi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM226354(US9328096, 47)
Affinity DataIC50:  10nMAssay Description:Inhibition of TRKA (unknown origin) in presence of [gamma33P]ATP by radiometric HotSpot assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetBDNF/NT-3 growth factors receptor(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM226354(US9328096, 47)
Affinity DataIC50:  1.80E+3nMAssay Description:Inhibition of TRKB (unknown origin) in presence of [gamma33P]ATP by radiometric HotSpot assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails PubMed
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM226354(US9328096, 47)
Affinity DataIC50:  10nMAssay Description:Antagonist activity at prolink-tagged TrkA (unknown origin) expressed in cells assessed as inhibition of NGF-induced receptor phosphorylation by meas...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB