BDBM24624 CHEMBL272980::MGCD-0103::MGCD0103::N-(2-aminophenyl)-4-({[4-(pyridin-3-yl)pyrimidin-2-yl]amino}methyl)benzamide::US10227295, Compound MGCD0103::US11377423, MGCD-0103::US9409858, MGCD0103::US9751832, MGCD0103::US9956192, Compound MGCD0103

SMILES Nc1ccccc1NC(=O)c1ccc(CNc2nccc(n2)-c2cccnc2)cc1

InChI Key InChIKey=HRNLUBSXIHFDHP-UHFFFAOYSA-N

Data  68 IC50  3 Other

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 24624   

TargetHistone deacetylase 1(Homo sapiens (Human))
University Of East Anglia

Curated by ChEMBL
LigandPNGBDBM24624(CHEMBL272980 | MGCD-0103 | MGCD0103 | N-(2-aminoph...)
Affinity DataIC50:  200nMAssay Description:Inhibition of human C-terminal Flag-tagged HDAC1 expressed in sf9 cells using Boc-Lys(Ac)-AMC as substrate preincubated for 10 mins followed by subst...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 2(Homo sapiens (Human))
University Of East Anglia

Curated by ChEMBL
LigandPNGBDBM24624(CHEMBL272980 | MGCD-0103 | MGCD0103 | N-(2-aminoph...)
Affinity DataIC50:  300nMAssay Description:Inhibition of human C-terminal Flag-tagged HDAC2 expressed in sf9 cells using Boc-Lys(Ac)-AMC as substrate preincubated for 10 mins followed by subst...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 3(Homo sapiens (Human))
University Of East Anglia

Curated by ChEMBL
LigandPNGBDBM24624(CHEMBL272980 | MGCD-0103 | MGCD0103 | N-(2-aminoph...)
Affinity DataIC50:  1.70E+3nMAssay Description:Inhibition of human C-terminal Flag-tagged HDAC3 expressed in sf9 cells using Boc-Lys(Ac)-AMC as substrate preincubated for 10 mins followed by subst...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 8(Homo sapiens (Human))
University Of East Anglia

Curated by ChEMBL
LigandPNGBDBM24624(CHEMBL272980 | MGCD-0103 | MGCD0103 | N-(2-aminoph...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human NH2-terminal His-tagged HDAC8 expressed in sf9 cells using Boc-Lys(Ac)-AMC as substrate preincubated for 10 mins followed by subs...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 4(Homo sapiens (Human))
University Of East Anglia

Curated by ChEMBL
LigandPNGBDBM24624(CHEMBL272980 | MGCD-0103 | MGCD0103 | N-(2-aminoph...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human NH2-terminal His6-tagged HDAC4 expressed in sf9 cells using Boc-Lys(Ac)-AMC as substrate preincubated for 10 mins followed by sub...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 5(Homo sapiens (Human))
University Of East Anglia

Curated by ChEMBL
LigandPNGBDBM24624(CHEMBL272980 | MGCD-0103 | MGCD0103 | N-(2-aminoph...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human NH2-terminal His6-tagged HDAC5 expressed in sf9 cells using Boc-Lys(Ac)-AMC as substrate preincubated for 10 mins followed by sub...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 7(Homo sapiens (Human))
University Of East Anglia

Curated by ChEMBL
LigandPNGBDBM24624(CHEMBL272980 | MGCD-0103 | MGCD0103 | N-(2-aminoph...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human NH2-terminal His6-tagged HDAC7 expressed in sf9 cells using Boc-Lys(Ac)-AMC as substrate preincubated for 10 mins followed by sub...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
University Of East Anglia

Curated by ChEMBL
LigandPNGBDBM24624(CHEMBL272980 | MGCD-0103 | MGCD0103 | N-(2-aminoph...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human NH2-terminal His-tagged HDAC6 expressed in sf9 cells using Boc-Lys(Ac)-AMC as substrate preincubated for 10 mins followed by subs...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 11(Homo sapiens (Human))
University Of East Anglia

Curated by ChEMBL
LigandPNGBDBM24624(CHEMBL272980 | MGCD-0103 | MGCD0103 | N-(2-aminoph...)
Affinity DataIC50:  600nMAssay Description:Inhibition of human C-terminal Flag-tagged HDAC11 expressed in sf9 cells using Boc-Lys(Ac)-AMC as substrate preincubated for 10 mins followed by subs...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed