BDBM26062 4-(2,3-dihydro-1,4-benzodioxin-6-yl)-5-[(5-nitrothiophen-2-yl)sulfanyl]-4H-1,2,4-triazol-3-ol::BI-83C11

SMILES O=c1[nH]nc(Sc2ccc([N+](=O)[O-])s2)n1-c1ccc2c(c1)OCCO2

InChI Key InChIKey=XVBXUPPITMGMCB-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 26062   

TargetMitogen-activated protein kinase 8(Human)
Burnham Institute For Medical Research

LigandChemical structure of BindingDB Monomer ID 26062BDBM26062(4-(2,3-dihydro-1,4-benzodioxin-6-yl)-5-[(5-nitroth...)
Affinity DataIC50: 2.50E+4nMpH: 7.8 T: 2°CAssay Description:Compound was evaluated for its ability to disrupt the interaction of pepJIP1 with JNK1 by using DELFIA assay. DELFIA is a heterogeneous assay whereby...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2008
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 8(Human)
Burnham Institute For Medical Research

LigandChemical structure of BindingDB Monomer ID 26062BDBM26062(4-(2,3-dihydro-1,4-benzodioxin-6-yl)-5-[(5-nitroth...)
Affinity DataIC50: 1.00E+5nMpH: 7.5 T: 2°CAssay Description:Compounds were tested for their ability to inhibit JNK1 phosphorylation of ATF2 in the Time-Resolved Fluorescence Resonance Energy Transfer (TR-FRET)...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2008
Entry Details Article
PubMed