BDBM263949 2-(5-(3-hydroxyphenyl)-1H- pyrazol-1-yl)isonicotinic acid::US10173996, Example 17::US9604961, Example 17::US9714230, 17::US9908865, Example 17

SMILES OC(=O)c1ccnc(c1)-n1nccc1-c1cccc(O)c1

InChI Key InChIKey=QVSDPEWGBYKEDU-UHFFFAOYSA-N

Data  6 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 263949   

TargetLysine-specific demethylase 5A(Homo sapiens (Human))
Celgene Quanticel Research

US Patent
LigandPNGBDBM263949(2-(5-(3-hydroxyphenyl)-1H- pyrazol-1-yl)isonicotin...)
Affinity DataIC50:  550nMAssay Description:The enzymatic assay of Jarid1A activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ability of test c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails US Patent
TargetLysine-specific demethylase 5B(Homo sapiens (Human))
Celgene Quanticel Research

US Patent
LigandPNGBDBM263949(2-(5-(3-hydroxyphenyl)-1H- pyrazol-1-yl)isonicotin...)
Affinity DataIC50:  550nMAssay Description:The ability of test compounds to inhibit the activity of Jarid1B was determined in 384-well plate format under the following reaction conditions: 0.8...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails US Patent
TargetLysine-specific demethylase 4C(Homo sapiens (Human))
Celgene

Curated by ChEMBL
LigandPNGBDBM263949(2-(5-(3-hydroxyphenyl)-1H- pyrazol-1-yl)isonicotin...)
Affinity DataIC50:  410nMAssay Description:Inhibition of KDM4C (unknown origin) preincubated with enzymeMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetLysine-specific demethylase 4A(Homo sapiens (Human))
Celgene Quanticel Research

US Patent
LigandPNGBDBM263949(2-(5-(3-hydroxyphenyl)-1H- pyrazol-1-yl)isonicotin...)
Affinity DataIC50:  550nMAssay Description:The ability of test compounds to inhibit the activity of JMJD2A was determined in 38-well plate format under the following reaction conditions: 2 nM ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetLysine-specific demethylase 5B(Homo sapiens (Human))
Celgene Quanticel Research

US Patent
LigandPNGBDBM263949(2-(5-(3-hydroxyphenyl)-1H- pyrazol-1-yl)isonicotin...)
Affinity DataIC50:  120nMAssay Description:Inhibition of KDM5B (unknown origin) preincubated with enzymeMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetLysine-specific demethylase 4C(Homo sapiens (Human))
Celgene

Curated by ChEMBL
LigandPNGBDBM263949(2-(5-(3-hydroxyphenyl)-1H- pyrazol-1-yl)isonicotin...)
Affinity DataIC50:  550nMAssay Description:The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails US Patent