BDBM26901 methyl 2-{8-[bis(2-chlorophenyl)methyl]-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl}acetate::spiropiperidine analogue, 22

SMILES COC(=O)CN1CN(c2ccccc2)C2(CCN(CC2)C(c2ccccc2Cl)c2ccccc2Cl)C1=O

InChI Key InChIKey=SLHIWQFTFLYARS-UHFFFAOYSA-N

Data  4 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 26901   

TargetNociceptin receptor(Human)
Schering-Plough Research Institute

LigandChemical structure of BindingDB Monomer ID 26901BDBM26901(methyl 2-{8-[bis(2-chlorophenyl)methyl]-4-oxo-1-ph...)
Affinity DataKi:  19.5nM ΔG°:  -10.4kcal/molepH: 7.4 T: 2°CAssay Description:IC50 values were obtained by fitting the competition binding curves according to a 4-parameter logistic model. Inhibition constants Ki were derived f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2009
Entry Details Article
PubMed
TargetMu-type opioid receptor(Human)
Schering-Plough Research Institute

LigandChemical structure of BindingDB Monomer ID 26901BDBM26901(methyl 2-{8-[bis(2-chlorophenyl)methyl]-4-oxo-1-ph...)
Affinity DataKi:  683nMAssay Description:IC50 values were obtained by fitting the competition binding curves according to a 4-parameter logistic model. Inhibition constants Ki were derived f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2009
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
Schering-Plough Research Institute

LigandChemical structure of BindingDB Monomer ID 26901BDBM26901(methyl 2-{8-[bis(2-chlorophenyl)methyl]-4-oxo-1-ph...)
Affinity DataKi:  2.27E+3nMAssay Description:IC50 values were obtained by fitting the competition binding curves according to a 4-parameter logistic model. Inhibition constants Ki were derived f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2009
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Human)
Schering-Plough Research Institute

LigandChemical structure of BindingDB Monomer ID 26901BDBM26901(methyl 2-{8-[bis(2-chlorophenyl)methyl]-4-oxo-1-ph...)
Affinity DataKi:  1.22E+5nMAssay Description:IC50 values were obtained by fitting the competition binding curves according to a 4-parameter logistic model. Inhibition constants Ki were derived f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2009
Entry Details Article
PubMed