BDBM273241 2-(4-(2-(7,8-dimethyl-[1,2,4]triazolo[1,5-a]pyridin-6-yl)-3-isopropyl-1H-indol-5-yl) piperidin-1-yl)acetamide::US10071079, Example 15::US10478424, Example 15::US11661431, Example A-1

SMILES CC(C)c1c([nH]c2ccc(cc12)C1CCN(CC(N)=O)CC1)-c1cn2ncnc2c(C)c1C

InChI Key InChIKey=SNFVHLQYHFQOEP-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 273241   

TargetToll-like receptor 8(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM273241(2-(4-(2-(7,8-dimethyl-[1,2,4]triazolo[1,5-a]pyridi...)
Affinity DataIC50:  1.40nMAssay Description:HEK-Blue-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducible...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetToll-like receptor 9(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM273241(2-(4-(2-(7,8-dimethyl-[1,2,4]triazolo[1,5-a]pyridi...)
Affinity DataIC50:  5.11E+3nMAssay Description:HEK-Blue-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducible...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetToll-like receptor 7(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM273241(2-(4-(2-(7,8-dimethyl-[1,2,4]triazolo[1,5-a]pyridi...)
Affinity DataIC50:  1.40nMAssay Description:HEK-Blue-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducible...More data for this Ligand-Target Pair
In DepthDetails US Patent