BDBM28422 (2S)-2-amino-4-({[(2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl}(methyl)sulfanylium)butanoate::AdoMet::S-Adenosylmethionine::S-adenosyl-L-[carboxy-14C]methionine::[14COOH]AdoMet
SMILES C[S+](CC[C@H](N)C([O-])=O)C[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12
InChI Key InChIKey=MEFKEPWMEQBLKI-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 28 hits for monomerid = 28422
Affinity DataIC50: 2.80nMAssay Description:Inhibition of CARM1 (unknown origin)More data for this Ligand-Target Pair
Affinity DataKd: 4nMAssay Description:Binding affinity to Escherichia coli metJ in presence of operator DNA complex by filter binding studyMore data for this Ligand-Target Pair
Affinity DataEC50: 17nMAssay Description:Binding affinity to Escherichia coli metJ assessed as protein dimer-DNA complex formation using F-metC operator DNA by fluorescence anisotropyMore data for this Ligand-Target Pair
Affinity DataIC50: 42nMAssay Description:Inhibition of PRMT4 (unknown origin)More data for this Ligand-Target Pair
TargetProtein arginine N-methyltransferase 1(Human)
Nanjing University of Chinese Medicine
Curated by ChEMBL
Nanjing University of Chinese Medicine
Curated by ChEMBL
Affinity DataIC50: 468nMAssay Description:Inhibition of PRMT1 (unknown origin)More data for this Ligand-Target Pair
TargetProtein arginine N-methyltransferase 7(Human)
Nanjing University of Chinese Medicine
Curated by ChEMBL
Nanjing University of Chinese Medicine
Curated by ChEMBL
Affinity DataIC50: 491nMAssay Description:Inhibition of PRMT7 (unknown origin)More data for this Ligand-Target Pair
TargetAdenosine receptor A1(Rat)
National Institute of Diabetes, Digestive and Kidney Diseases
Curated by PDSP Ki Database
National Institute of Diabetes, Digestive and Kidney Diseases
Curated by PDSP Ki Database
TargetProtein arginine N-methyltransferase 8(Human)
Nanjing University of Chinese Medicine
Curated by ChEMBL
Nanjing University of Chinese Medicine
Curated by ChEMBL
Affinity DataIC50: 759nMAssay Description:Inhibition of PRMT8 (unknown origin)More data for this Ligand-Target Pair
TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
Nanjing University of Chinese Medicine
Curated by ChEMBL
Nanjing University of Chinese Medicine
Curated by ChEMBL
Affinity DataIC50: 793nMAssay Description:Inhibition of recombinant N-terminal FLAG-tagged human full-length PRMT5/full length human MEP50 extracted from baculovirus expression system using [...More data for this Ligand-Target Pair
TargetProtein arginine N-methyltransferase 6(Human)
Nanjing University of Chinese Medicine
Curated by ChEMBL
Nanjing University of Chinese Medicine
Curated by ChEMBL
Affinity DataIC50: 1.26E+3nMAssay Description:Inhibition of PRMT6 (unknown origin)More data for this Ligand-Target Pair
TargetTransmembrane and immunoglobulin domain-containing 3(Rat)
National Institute of Diabetes, Digestive and Kidney Diseases
Curated by PDSP Ki Database
National Institute of Diabetes, Digestive and Kidney Diseases
Curated by PDSP Ki Database
TargetAdenosine receptor A2a(Rat)
National Institute of Diabetes, Digestive and Kidney Diseases
Curated by PDSP Ki Database
National Institute of Diabetes, Digestive and Kidney Diseases
Curated by PDSP Ki Database
Affinity DataKd: 4.80E+3nMAssay Description:Activity of human wild type PNMT assessed as phenylethanolamine methylationMore data for this Ligand-Target Pair
TargetProtein arginine N-methyltransferase 3(Human)
Nanjing University of Chinese Medicine
Curated by ChEMBL
Nanjing University of Chinese Medicine
Curated by ChEMBL
Affinity DataIC50: 5.18E+3nMAssay Description:Inhibition of PRMT3 (unknown origin)More data for this Ligand-Target Pair
Affinity DataKd: 5.80E+3nMpH: 7.5 T: 2°CAssay Description:For standard ITC analysis of ligand binding, proteins were dialyzed overnight in 25 mm Hepes (pH 7.5), 100 mm NaCl, 5 mm -mercaptoethanol, and 5% gly...More data for this Ligand-Target Pair
Affinity DataKd: 6.10E+3nMpH: 7.5 T: 2°CAssay Description:For standard ITC analysis of ligand binding, proteins were dialyzed overnight in 25 mm Hepes (pH 7.5), 100 mm NaCl, 5 mm -mercaptoethanol, and 5% gly...More data for this Ligand-Target Pair
Affinity DataKd: 8.20E+3nMpH: 7.5 T: 2°CAssay Description:For standard ITC analysis of ligand binding, proteins were dialyzed overnight in 25 mm Hepes (pH 7.5), 100 mm NaCl, 5 mm -mercaptoethanol, and 5% gly...More data for this Ligand-Target Pair
Affinity DataKd: 1.07E+4nMpH: 7.5 T: 2°CAssay Description:For standard ITC analysis of ligand binding, proteins were dialyzed overnight in 25 mm Hepes (pH 7.5), 100 mm NaCl, 5 mm -mercaptoethanol, and 5% gly...More data for this Ligand-Target Pair
Affinity DataKd: 1.14E+4nMpH: 7.5 T: 2°CAssay Description:For standard ITC analysis of ligand binding, proteins were dialyzed overnight in 25 mm Hepes (pH 7.5), 100 mm NaCl, 5 mm -mercaptoethanol, and 5% gly...More data for this Ligand-Target Pair
Affinity DataIC50: 1.20E+4nMAssay Description:Inhibition of GST-fused human recombinant PRMT1 after 90 mins by SDS-PAGE based scintillation countingMore data for this Ligand-Target Pair
Affinity DataKd: 1.66E+4nMpH: 7.5 T: 2°CAssay Description:For standard ITC analysis of ligand binding, proteins were dialyzed overnight in 25 mm Hepes (pH 7.5), 100 mm NaCl, 5 mm -mercaptoethanol, and 5% gly...More data for this Ligand-Target Pair
Affinity DataKd: 1.91E+4nMpH: 7.5 T: 2°CAssay Description:For standard ITC analysis of ligand binding, proteins were dialyzed overnight in 25 mm Hepes (pH 7.5), 100 mm NaCl, 5 mm -mercaptoethanol, and 5% gly...More data for this Ligand-Target Pair
Affinity DataKd: 2.67E+4nMpH: 7.5 T: 2°CAssay Description:For standard ITC analysis of ligand binding, proteins were dialyzed overnight in 25 mm Hepes (pH 7.5), 100 mm NaCl, 5 mm -mercaptoethanol, and 5% gly...More data for this Ligand-Target Pair
Affinity DataKd: 4.72E+4nMpH: 7.5 T: 2°CAssay Description:For standard ITC analysis of ligand binding, proteins were dialyzed overnight in 25 mm Hepes (pH 7.5), 100 mm NaCl, 5 mm -mercaptoethanol, and 5% gly...More data for this Ligand-Target Pair
Affinity DataKi: 6.00E+4nMAssay Description:In vitro inhibitory activity against S-adenosyl-L-methionine decarboxylase using liver from rat in presence of 1 mM putrescineMore data for this Ligand-Target Pair
Affinity DataKi: 1.64E+5nMAssay Description:Kinetic constant was measured for PMII of Leishmania donovani promastigotes using protein extracted from the 12000 g pellet (P12).More data for this Ligand-Target Pair
Affinity DataKi: 1.64E+5nMAssay Description:Kinetic constant was measured for PMII of Leishmania donovani promastigotes using protein extracted from the 12000 g pellet (P12).More data for this Ligand-Target Pair
Affinity DataKi: 3.00E+5nMAssay Description:In vitro inhibitory activity against S-adenosyl-L-methionine decarboxylase using liver from rat in absence of putrescineMore data for this Ligand-Target Pair
Activity Spreadsheet -- ITC Data from BindingDB
Found 9 hits for monomerid = 28422
ITC DataΔG°: -6.69kcal/mole −TΔS°: -1.99kcal/mole ΔH°: -4.54kcal/mole
pH: 7.5 T: 5.00°C
pH: 7.5 T: 5.00°C
ITC DataΔG°: -6.69kcal/mole −TΔS°: 0.0676kcal/mole ΔH°: -6.69kcal/mole
pH: 7.5 T: 10.00°C
pH: 7.5 T: 10.00°C
ITC DataΔG°: -6.45kcal/mole −TΔS°: 2.41kcal/mole ΔH°: -8.84kcal/mole
pH: 7.5 T: 15.00°C
pH: 7.5 T: 15.00°C
ITC DataΔG°: -6.45kcal/mole −TΔS°: 4.76kcal/mole ΔH°: -11.1kcal/mole
pH: 7.5 T: 20.00°C
pH: 7.5 T: 20.00°C
ITC DataΔG°: -6.21kcal/mole −TΔS°: 7.83kcal/mole ΔH°: -14.3kcal/mole
pH: 7.5 T: 25.00°C
pH: 7.5 T: 25.00°C
ITC DataΔG°: -5.73kcal/mole −TΔS°: 9.27kcal/mole ΔH°: -15.1kcal/mole
pH: 7.5 T: 4.00°C
pH: 7.5 T: 4.00°C
ITC DataΔG°: -6.21kcal/mole −TΔS°: 6.22kcal/mole ΔH°: -12.5kcal/mole
pH: 7.5 T: 4.00°C
pH: 7.5 T: 4.00°C
ITC DataΔG°: -6.69kcal/mole −TΔS°: 6.62kcal/mole ΔH°: -13.6kcal/mole
pH: 7.5 T: 4.00°C
pH: 7.5 T: 4.00°C
ITC DataΔG°: -6.93kcal/mole −TΔS°: 5.49kcal/mole ΔH°: -12.7kcal/mole
pH: 7.5 T: 4.00°C
pH: 7.5 T: 4.00°C