BDBM291899 N-(benzofuran-4-ylmethyl)-8-(4-(methylsulfonyl)phenyl)-[1,2,4]triazolo[4,3-c]pyrimidin-5-amine::US11207325, Example 214::US9580437, Example 214

SMILES CS(=O)(=O)c1ccc(cc1)-c1cnc(NCc2cccc3occc23)n2cnnc12

InChI Key InChIKey=ZCKREKXDGMDDHF-UHFFFAOYSA-N

Data  4 IC50

PDB links: 7 PDB IDs match this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 291899   

LigandPNGBDBM291899(N-(benzofuran-4-ylmethyl)-8-(4-(methylsulfonyl)phe...)
Affinity DataIC50:  37.4nMpH: 8.0Assay Description:To assess the compounds potency in the EED-H3K27Me3 competition binding assay, compounds were serially diluted 3-fold in DMSO to obtain a total of tw...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetPolycomb protein EED(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM291899(N-(benzofuran-4-ylmethyl)-8-(4-(methylsulfonyl)phe...)
Affinity DataIC50:  22.5nMAssay Description:Representative compounds of the present disclosure were serially and separately diluted 3-fold in DMSO to obtain a total of eight or twelve concentra...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetPolycomb protein EED(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM291899(N-(benzofuran-4-ylmethyl)-8-(4-(methylsulfonyl)phe...)
Affinity DataIC50:  37.4nMAssay Description:To assess the compounds potency in the EED-H3K27Me3 competition binding assay, compounds were serially diluted 3-fold in DMSO to obtain a total of tw...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
LigandPNGBDBM291899(N-(benzofuran-4-ylmethyl)-8-(4-(methylsulfonyl)phe...)
Affinity DataIC50:  22.5nMpH: 8.0Assay Description:Representative compounds of the present disclosure were serially and separately diluted 3-fold in DMSO to obtain a total of eight or twelve concentra...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB