BDBM309787 (R)-3-(4-(1-cyclopentylpiperidin-4-yl)phenylamino)-5-(3-(3-methyl-2-oxoimidazolidin-1-yl)piperidin-1-yl)pyrazine-2-carboxamide::US9656988, Example 256

SMILES CN1CCN([C@@H]2CCCN(C2)c2cnc(C(N)=O)c(Nc3ccc(cc3)C3CCNCC3)n2)C1=O

InChI Key InChIKey=JCGXVYWABUYORV-HXUWFJFHSA-N

Data  6 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 309787   

TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Pharmacyclics

US Patent
LigandPNGBDBM309787((R)-3-(4-(1-cyclopentylpiperidin-4-yl)phenylamino)...)
Affinity DataIC50: <10nMAssay Description:Human Btk kinase (Genbank accession # NP_000052) was purified from insect cells as a full-length construct containing a N-terminal 6×-His tag. Btk ki...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Pharmacyclics

US Patent
LigandPNGBDBM309787((R)-3-(4-(1-cyclopentylpiperidin-4-yl)phenylamino)...)
Affinity DataIC50: <10nMAssay Description:Human Btk kinase (Genbank accession # NP_000052) was purified from insect cells as a full-length construct containing a N-terminal 6×-His tag. Btk ki...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Pharmacyclics

US Patent
LigandPNGBDBM309787((R)-3-(4-(1-cyclopentylpiperidin-4-yl)phenylamino)...)
Affinity DataIC50:  55nMAssay Description:The degree of inhibition of a panel of kinases is determined using the in vitro HotSpot kinase assay (purified enzymes, 33P-ATP, an appropriate subst...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails US Patent
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Pharmacyclics

US Patent
LigandPNGBDBM309787((R)-3-(4-(1-cyclopentylpiperidin-4-yl)phenylamino)...)
Affinity DataIC50:  550nMAssay Description:The degree of inhibition of a panel of kinases is determined using the in vitro HotSpot kinase assay (purified enzymes, 33P-ATP, an appropriate subst...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails US Patent
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Pharmacyclics

US Patent
LigandPNGBDBM309787((R)-3-(4-(1-cyclopentylpiperidin-4-yl)phenylamino)...)
Affinity DataIC50:  55nMAssay Description:The degree of inhibition of a panel of kinases is determined using the in vitro HotSpot kinase assay (purified enzymes, 33P-ATP, an appropriate subst...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK [C481S](Homo sapiens (Human))
Pharmacyclics

US Patent
LigandPNGBDBM309787((R)-3-(4-(1-cyclopentylpiperidin-4-yl)phenylamino)...)
Affinity DataIC50: <10nMAssay Description:The degree of inhibition of a panel of kinases is determined using the in vitro HotSpot kinase assay (purified enzymes, 33P-ATP, an appropriate subst...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB