BDBM31811 Apogossypol derivative, 8s

SMILES Cc1cc2c(C(=O)NC3Cc4ccccc4C3)c(O)c(O)cc2c(O)c1-c1c(C)cc2c(C(=O)NC3Cc4ccccc4C3)c(O)c(O)cc2c1O

InChI Key InChIKey=IYKAYCYVRWTIHM-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 31811   

TargetBcl-2-related protein A1(Homo sapiens (Human))
Burnham Institute For Medical Research

LigandPNGBDBM31811(Apogossypol derivative, 8s)
Affinity DataIC50:  670nMT: 2°CAssay Description:FPAs were performed using various concentrations of GST-Bcl-2 family proteins, incubated with FITC-conjugated peptide substrates in the presence of i...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Homo sapiens (Human))
Burnham Institute For Medical Research

LigandPNGBDBM31811(Apogossypol derivative, 8s)
Affinity DataIC50:  350nMpH: 7.4 T: 2°CAssay Description:FPAs were performed using various concentrations of GST-Bcl-2 family proteins, incubated with FITC-conjugated peptide substrates in the presence of i...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetApoptosis regulator Bcl-2(Homo sapiens (Human))
Burnham Institute For Medical Research

LigandPNGBDBM31811(Apogossypol derivative, 8s)
Affinity DataIC50:  700nMpH: 7.4 T: 2°CAssay Description:FPAs were performed using various concentrations of GST-Bcl-2 family proteins, incubated with FITC-conjugated peptide substrates in the presence of i...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBcl-2-like protein 1(Homo sapiens (Human))
Burnham Institute For Medical Research

LigandPNGBDBM31811(Apogossypol derivative, 8s)
Affinity DataIC50:  850nMpH: 7.4 T: 2°CAssay Description:FPAs were performed using various concentrations of GST-Bcl-2 family proteins, incubated with FITC-conjugated peptide substrates in the presence of i...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed