BDBM319578 7-methoxy-1-{[(1S,5S)-3-oxo-2-azabicyclo[3.1.0]hex-1-yl]methoxylisoquinoline-6-carboxamide::US10174000, Example 30

SMILES COc1cc2c(OC[C@]34C[C@H]3CC(=O)N4)nccc2cc1C(N)=O

InChI Key InChIKey=NVZQDGCTPMTAPF-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 319578   

TargetInterleukin-1 receptor-associated kinase 4(Human)
Pfizer

US Patent
LigandPNGBDBM319578(7-methoxy-1-{[(1S,5S)-3-oxo-2-azabicyclo[3.1.0]hex...)
Affinity DataIC50: 151nMAssay Description:This is an in vitro assay to measure IRAK4 enzymatic activity utilizing the DELFIA (Dissociation-Enhanced Lanthanide Fluorescent Immunoassay, Perkin-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/15/2019
Entry Details
US Patent

TargetInterleukin-1 receptor-associated kinase 4(Human)
Pfizer

US Patent
LigandPNGBDBM319578(7-methoxy-1-{[(1S,5S)-3-oxo-2-azabicyclo[3.1.0]hex...)
Affinity DataIC50: 4.30E+3nMAssay Description:This is an in vitro assay to measure IRAK4 enzymatic activity utilizing the DELFIA (Dissociation-Enhanced Lanthanide Fluorescent Immunoassay, Perkin-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/15/2019
Entry Details
US Patent