BDBM328810 (S)-1,1,1-trifluoro-2-methylpropan-2-yl (2-(cyclopropanesulfonamidomethyl)- 4-((3- (methylsulfonyl)phenyl)sulfonyl)-3,4- dihydro-2H-benzo[b][1,4]oxazin-6- yl)carbamate::US9663502, 36F

SMILES CC(C)(OC(=O)Nc1ccc2O[C@@H](CNS(=O)(=O)C3CC3)CN(c2c1)S(=O)(=O)c1cccc(c1)S(C)(=O)=O)C(F)(F)F

InChI Key InChIKey=WXMCPVWQVGOVNX-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 328810   

TargetNuclear receptor ROR-gamma(Human)
Lycera

US Patent
LigandPNGBDBM328810(US9663502, 36F | (S)-1,1,1-trifluoro-2-methylpropa...)
Affinity DataIC50: 6.39nMAssay Description:The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., a biochemical TR-FRET assay....More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2019
Entry Details
US Patent