BDBM328996 1137477-07-6::US11787792, Compound Y-081::US9663503, Compound Y-081

SMILES COC(=O)c1cnc(Nc2cnc(cn2)C#N)cc1NCC1CNCCO1

InChI Key InChIKey=PHPWNBVMNTWSJB-UHFFFAOYSA-N

Data  6 IC50

PDB links: 1 PDB ID matches this monomer.

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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 328996   

TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Cancer Research Technology

US Patent
LigandPNGBDBM328996(1137477-07-6 | US11787792, Compound Y-081 | US9663...)
Affinity DataIC50:  2nMAssay Description:CHK1 kinase activity was measured in a microfluidic assay that monitors the separation of a phosphorylated product from its substrate. The assay was ...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Cancer Research Technology

US Patent
LigandPNGBDBM328996(1137477-07-6 | US11787792, Compound Y-081 | US9663...)
Affinity DataIC50:  2.20nMAssay Description:Inhibition of CHK1 (unknown origin) using 5-FAM-KKKVSRSGLYRSPSMPENLNRPR-COOH peptide as substrate incubated for 1 hr in presence of ATP by caliper mi...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Cancer Research Technology

US Patent
LigandPNGBDBM328996(1137477-07-6 | US11787792, Compound Y-081 | US9663...)
Affinity DataIC50:  2nMAssay Description:CHK1 kinase activity was measured in a microfluidic assay that monitors the separation of a phosphorylated product from its substrate. The assay was ...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Cancer Research Technology

US Patent
LigandPNGBDBM328996(1137477-07-6 | US11787792, Compound Y-081 | US9663...)
Affinity DataIC50:  310nMAssay Description:Inhibition of CHK1 in human HT-29 cells assessed as abrogation of etoposide-induced G2 checkpoint arrest by ELISAMore data for this Ligand-Target Pair
TargetCyclin-dependent kinase 1(Homo sapiens (Human))
Sareum

Curated by ChEMBL
LigandPNGBDBM328996(1137477-07-6 | US11787792, Compound Y-081 | US9663...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CDK1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk2(Homo sapiens (Human))
Sareum

Curated by ChEMBL
LigandPNGBDBM328996(1137477-07-6 | US11787792, Compound Y-081 | US9663...)
Affinity DataIC50:  5.00E+3nMAssay Description:Inhibition of CHK2 (unknown origin) using Biotin-KKKVSRSGLYRSPSMPENLNRPR peptide as substrate incubated for 30 mins in presence of ATP by dissociatio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed