BDBM351570 N-(4-methyl-3-(1H-1,2,4-triazol-5-yl)thiophen-2-yl)-2-(2-oxo-3,4-dihydroquinolin-1(2H)-yl)acetamide::US9796706, Compound 14

SMILES Cc1csc(NC(=O)CN2C(=O)CCc3ccccc23)c1-c1ncn[nH]1

InChI Key InChIKey=HJUDFJRTVGXBRF-UHFFFAOYSA-N

Data  3 IC50

PDB links: 1 PDB ID matches this monomer.

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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 351570   

TargetMitogen-activated protein kinase 10(Homo sapiens (Human))
Imago Pharmaceuticals

US Patent
LigandPNGBDBM351570(N-(4-methyl-3-(1H-1,2,4-triazol-5-yl)thiophen-2-yl...)
Affinity DataIC50: <100nMAssay Description:(1) Assay buffer #1 with 0.0025% Tween and 1 mM DTT was prepared using JNK buffer stock solution.(2) Assay buffer #2 with 0.025% BSA was prepared usi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetMitogen-activated protein kinase 9(Homo sapiens (Human))
Imago Pharmaceuticals

US Patent
LigandPNGBDBM351570(N-(4-methyl-3-(1H-1,2,4-triazol-5-yl)thiophen-2-yl...)
Affinity DataIC50:  5.05E+3nMAssay Description:(1) Assay buffer #1 with 0.0025% Tween and 1 mM DTT was prepared using JNK buffer stock solution.(2) Assay buffer #2 with 0.025% BSA was prepared usi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetMitogen-activated protein kinase 8(Homo sapiens (Human))
Imago Pharmaceuticals

US Patent
LigandPNGBDBM351570(N-(4-methyl-3-(1H-1,2,4-triazol-5-yl)thiophen-2-yl...)
Affinity DataIC50: <100nMAssay Description:(1) Assay buffer #1 with 0.0025% Tween and 1 mM DTT was prepared using JNK buffer stock solution.(2) Assay buffer #2 with 0.025% BSA was prepared usi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB