BDBM359494 4-(1-(2-chloro-6- cyclopropylbenzoyl)- 1,4,5,6,7,8- hexahydrocyclohepta[c]pyrazol- 3-yl)-3-fluorobenzoic acid::US10221142, Example 1K

SMILES OC(=O)c1ccc(-c2nn(C(=O)c3c(Cl)cccc3C3CC3)c3CCCCCc23)c(F)c1

InChI Key InChIKey=UHHYRRVNIBCTSA-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 359494   

TargetNuclear receptor ROR-gamma(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM359494(4-(1-(2-chloro-6- cyclopropylbenzoyl)- 1,4,5,6,7,8...)
Affinity DataIC50: 21.6nMAssay Description:The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., biochemical TR-FRET assay. I...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2019
Entry Details
US Patent