BDBM361535 (R)-3-((1R,3R)-1-(5-fluoro-2-(2-((3-fluoropropyl)amino)ethoxy)-3-methylpyridin-4-yl)-3-methyl-1,3,4,9-tetrahydro-2H-pyrido[3,4-b]indol-2-yl)-2-methylpropanoic acid::US10221173, Example 127::US10590132, Example 127::US11046689, Example 127

SMILES Cc1c(c(cnc1OCCNCCCF)F)[C@@H]2c3c(c4ccccc4[nH]3)C[C@H](N2C[C@@H](C)C(=O)O)C

InChI Key InChIKey=JMHAEPDWKOSCPH-UHFFFAOYSA-N

Data  4 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 361535   

TargetEstrogen receptor [307-554](Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 361535BDBM361535((R)-3-((1R,3R)-1-(5-fluoro-2-(2-((3-fluoropropyl)a...)
Affinity DataIC50: 1.80nMAssay Description:ERα: The ability of compounds to bind to isolated Estrogen Receptor Alpha Ligand binding domain (ER alpha-LBD (GST)) was assessed in competition...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2020
Entry Details
US Patent

TargetEstrogen receptor(Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 361535BDBM361535((R)-3-((1R,3R)-1-(5-fluoro-2-(2-((3-fluoropropyl)a...)
Affinity DataIC50: 1.80nMAssay Description:The ability of compounds to bind to isolated Estrogen Receptor Alpha Ligand binding domain (ER alpha-LBD (GST)) was assessed in competition assays us...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2021
Entry Details
US Patent

TargetEstrogen receptor(Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 361535BDBM361535((R)-3-((1R,3R)-1-(5-fluoro-2-(2-((3-fluoropropyl)a...)
Affinity DataIC50: 1.80nMAssay Description:The ability of compounds to bind to isolated Estrogen Receptor Alpha Ligand binding domain (ER alpha LBD (GST)) was assessed in competition assays us...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/27/2019
Entry Details
US Patent